相关实验视频

Updated: May 28, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

动脉样硬化治疗的创新方法:利用传统中医药来准长非编码RNA

Xiaofang Chen¹, Wenyan Ding², Yifan Liu¹

¹Research Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|February 12, 2025

概括

长非编码RNAs (lncRNAs) 与动脉样硬化 (AS) 病变发生有关. 传统中医 (TCM) 通过准lncRNAs来预防和治疗AS,提供了潜在的治疗策略.

科学领域:

心血管研究研究心血管研究
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

动脉样硬化 (AS) 是心血管疾病死亡的主要原因.
长非编码RNAs (lncRNAs) 是细胞平衡和疾病过程的关键调节者.
新出现的证据将 lncRNA 与动脉样硬化病变产生联系起来.

研究的目的:

研究 lncRNAs 在 AS 发育中的作用.
审查传统中医药 (TCM) 在调节AS治疗中 lncRNAs 的治疗潜力.
在TCM和lncRNA研究中确定AS的新型治疗点.

主要方法:

在主要的科学数据库 (PubMed,科学网等) 进行全面的文献搜索. ) 的情况.
对lncRNAs,AS和TCM的研究进行系统审查.
关键词的分析包括"动脉样硬化"",传统中医"",lncRNAs"和"心血管疾病".

主要成果:

lncRNAs通过内皮功能障碍,血管光滑肌肉细胞增殖,巨细胞泡细胞形成和脂质代谢失调促进AS.
确定了16种草本单体和6种具有潜在治疗应用的中国草本化合物.
评估了相关TCM组件的毒理学概况.

结论:

调节lncRNAs为AS治疗提供了一个有前途的途径.
在TCM中,草本单体,提取物和配方显示出在AS中准lncRNA的显著潜力.
这项研究支持在心血管疾病管理中扩大TCM应用.

关键词:

有效成分活性成分有效成分动脉样硬化是一种动脉样硬化.心血管疾病的心血管疾病.长的非编码RNA是什么?毒理学毒理学毒理学传统的中国医学是传统的中国医学.

更多相关视频

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...