精神分裂症和双相情感障碍中的心肌力学:需要填补的空白
Andrea Faggiano1, Elisa Gherbesi2, Stefano Carugo1
1Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Italy; Department of Clinical Sciences and Community Health, University of Milano, Italy.
Schizophrenia research
|February 12, 2025
概括
全球纵向应变 (GLS) 在精神分裂症和双相情感障碍患者中检测到早期心脏功能障碍,比左心室喷射率 (LVEF) 更好. 斑点跟踪回声心脏图 (STE) 是评估这些人群心肌变形的敏感工具.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 在没有先前心脏病的精神分裂症和双相情感障碍患者中,临床下心脏损伤,特别是心肌变形,理解程度不佳.
- 标准心声回声和MRI在检测这些患者早期心脏功能障碍方面存在局限性.
研究的目的:
- 在患有精神分裂症和双相情感障碍的患者中,系统地审查使用斑点跟踪回声心脏学 (STE) 对心肌变形的证据.
- 为了确定全球纵向应变 (GLS) 是否在这个人群中比左心室喷射率 (LVEF) 更敏感的静脉功能障碍指标.
主要方法:
- 在主要的文献数据库 (PubMed,Ovid,EMBASE,Cochrane Library) 进行系统的文献搜索,截至2024年8月31日.
- 在研究选择和数据提取方面遵循PRISMA指南.
- 包括6项研究,535名患者 (185名精神分裂症,350名双相情感障碍) 和153名健康对照.
主要成果:
- 全球纵向菌株 (GLS) 与左心室喷射分数 (LVEF) 相比,在检测早期缩功能障碍方面表现出更高的灵敏度.
- 两项研究评估了抗精神病治疗的影响,GLS反映了治疗对缩功能的影响.
- 在精神分裂症和双相情感障碍患者中,GLS比LVEF更有效地确定了亚临床缩功能障碍.
结论:
- 使用STE对左心室 (LV) 机制的评估在精神分裂症和双相情感障碍中未得到充分利用.
- STE,特别是GLS,可以比LVEF更有效地揭露亚临床缩功能障碍.
- 需要进一步的研究来调查STE在这些患者群体中早期检测LV缩功能障碍方面的作用.
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