基于大米的纳米乳液白蛋白-甜叶多-德克斯复合物:相互作用机制,稳定性和阿斯丁释放行为
Junren Wen1, Yong Sui2, Jianbin Shi2
1Key Laboratory of Agricultural Products Cold Chain Logistics, Ministry of Agriculture and Rural Affairs, Institute of Agro-Products Processing and Nuclear agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan 430064, China; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Food chemistry
|February 12, 2025
概括
米白蛋白,甜叶多和德克斯形成一个三元复合体,以稳定乳液中的阿斯丁 (AST). 这种复合物增强了AST的稳定性,减少了脂质氧化,并改善了消化过程中的输送.
科学领域:
- 食品科学 食品科学 食品科学
- 生物材料工程 生物材料工程
- 营养生物化学 营养生物化学
背景情况:
- 阿斯塔克桑丁 (AST) 是一种脂性生物活性化合物,具有显著的健康益处,但在食品系统中稳定性差,生物可访问性低.
- 乳液系统通常用于AST输送,但它们的稳定性和AST的保留可能具有挑战性.
- 开发有效的传递系统对于最大限度地发挥AST的治疗潜力至关重要.
研究的目的:
- 结合大米白蛋白 (RBA),甜叶多 (SPLPs) 和德克斯,以创建一个三元复合体,以增强阿斯塔克桑 (AST) 输送.
- 研究这种三元复合体对乳液系统中AST的稳定性,生物可访问性和环境应激抵抗性的影响.
- 评估开发的乳液系统在防止脂质氧化和促进肠道消化过程中AST释放方面的有效性.
主要方法:
- 使用RBA,SPLPs和dextran形成三元共价和非共价复合体.
- 三元复合结构的表征,包括多糖合物接种,二次结构和疏水性群体暴露.
- 准备和评估由三元复合体稳定的AST载荷乳液系统.
- 通过颗粒大小分析,奶油指数和长期储存试验来评估乳液稳定性.
- 测量AST保留,抑制脂质氧化和体外肠道消化释放.
主要成果:
- RBA-SPLPs-Dex三元共价复合物表现出有利于乳液稳定性的特性,包括更高的多糖体接种,更松散的二次结构和暴露的疏水组.
- 经RBA-SPLPs修改为50 mg/mL的德克斯 (Dextran50) 稳定后的乳液在长期储存期间显示了颗粒大小和奶油指数的减少.
- 与未经修改的模型相比,阿斯塔克桑保持率提高了59.43%,显著抑制了脂质氧化.
- 德克斯50增强了乳液的环境应激稳定性,并在模拟肠道消化过程中表现出更有效的AST释放.
结论:
- 由RBA,SPLPs和德克斯形成的三级复合物在乳液系统中有效稳定阿斯塔丁.
- 德克斯50修饰的乳液系统提供了对降解和氧化的优越保护,从而改善了阿斯塔克桑的生物可访问性.
- 这些先进的乳液系统对于有效地输送像阿斯塔克桑这样的脂性生物活性成分具有显著的前景.
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