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评估生物年龄的方法 - 一个系统的审查
Rebecca Zurbuchen1, Anna von Däniken1, Heidrun Janka2
1University of Bern, Bern, Switzerland.
Maturitas
|February 12, 2025
概括
生物年龄提供了比时间年龄更准确的健康评估. 目前的方法有所不同,Klemera和Doubal有所不同.
科学领域:
- 老年学和衰老研究.
- 生物标志物分析和健康评估.
- 公共卫生和预防医学.
背景情况:
- 生物年龄被认为是比时间年龄更准确的衰老指标.
- 现有的确定生物年龄的方法依赖于各种生物标志物.
- 需要对这些方法进行全面的比较,以建立一个黄金标准.
研究的目的:
- 审查和比较评估成人生物年龄的方法.
- 分析生物年龄评估中使用的生物标志物.
- 确定生物年龄计算的最佳目标,并建立一个黄金标准.
主要方法:
- 在Medline,Embase,Cochrane图书馆,科学网和临床试验.gov.gov 的文献搜索.
- 包括56项使用测试电池和统计方法计算生物年龄的研究.
- 对所有包含的研究进行偏差风险评估.
主要成果:
- 常见的方法包括克莱梅拉和杜巴尔的方法,主要成分分析,多重线性回归,PhenoAge和霍希希尔德的方法.
- 克莱梅拉和杜巴尔的方法在审查的方法中显示出最高的可靠性.
- 生物年龄分数的差异源于统计方法和生物标志物选择,特别是包括时间年龄.
结论:
- 目前还没有确立衡量生物年龄的黄金标准.
- 进一步的研究是必要的,以发展一个共识的黄金标准方法.
- 生物年龄评估有可能更准确地评估个体的衰老过程和功能状态.
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