Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

66.7K
Overview
66.7K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K
Vaccinations01:51

Vaccinations

43.8K
Overview
43.8K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

940
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
940
Immunological Memory01:23

Immunological Memory

518
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
518

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Ferroptosis is a Physiologic Vulnerability of Iron-Recycling Macrophages.

bioRxiv : the preprint server for biology·2026
Same author

Macrophage recruitment is a hallmark of non-syndromic myxomatous mitral valve disease.

Cardiovascular research·2026
Same author

Validation and refinement of existing methods for timed mating and early pregnancy detection in guinea pigs.

PloS one·2026
Same author

Kupffer cells control neonatal hepatic metabolism via Igf1 signaling.

Development (Cambridge, England)·2025
Same author

Maternal diet shapes the development and identity of tissue-resident macrophages.

Trends in immunology·2025
Same author

Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis.

Gut·2025

相关实验视频

Updated: May 28, 2025

T Cells Capture Bacteria by Transinfection from Dendritic Cells
11:39

T Cells Capture Bacteria by Transinfection from Dendritic Cells

Published on: January 13, 2016

11.8K

细菌转移促进训练的免疫力.

Maria Francesca Viola1, Elvira Mass1

  • 1Developmental Biology of the Immune System, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany.

Immunity
|February 12, 2025
PubMed
概括

在大肠炎期间,细菌突破肠道屏障,可以改变骨髓免疫细胞前体. 这种依赖于Mincle的信号驱动长期的免疫变化,影响整体免疫力.

科学领域:

  • 免疫学 免疫学 免疫学
  • 微生物学 微生物学
  • 细胞生物学 细胞生物学

背景情况:

  • 粘膜屏障,如肠道内膜,通常会阻止细菌进入更深层的组织.
  • 这些屏障的突破可能导致炎症和感染,可能会影响系统免疫力.

研究的目的:

  • 为了研究细菌如何突破肠道屏障影响免疫细胞的发展.
  • 了解参与细菌诱导的免疫重编程的信号通路.

主要方法:

  • 这项研究利用大肠炎模型来模仿肠道屏障功能障碍.
  • 研究了Mincle信号在骨髓内的免疫细胞前体中的作用.

主要成果:

  • 细菌通过受损的肠道屏障转移,重新编程了骨髓中的免疫细胞前体.
  • 这种重新编程依赖于Mincle信号传递,这是一个参与天生的免疫力的受体.

结论:

  • 在肠道炎症期间的细菌转位可以诱导骨髓免疫细胞池的持久变化.
  • 微粒依赖信号传递是肠道细菌影响全身免疫力的关键机制.

更多相关视频

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

2.4K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

10.5K

相关实验视频

Last Updated: May 28, 2025

T Cells Capture Bacteria by Transinfection from Dendritic Cells
11:39

T Cells Capture Bacteria by Transinfection from Dendritic Cells

Published on: January 13, 2016

11.8K
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

2.4K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

10.5K