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维生素D补充剂在多发性硬化症中调解了向抗炎性细胞因子反应的转变

Suhail Al-Shammri^1,2, Arpita Chattopadhyay², Raj Raghupathy³

¹Division of Neurology, Mubarak Al Kabeer Hospital Kuwait, Jabriya, Kuwait.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre

|February 12, 2025

概括

新确诊的多发性硬化症 (MS) 患者的维生素D补充剂减少了促炎性细胞因子. 这表明维生素D (Vit-D) 可能通过调节免疫反应来帮助管理MS.

科学领域:

神经免疫学神经免疫学
内分泌学在内分泌学.

背景情况:

多发性硬化症 (MS) 是一种自身免疫性疾病,其特征是免疫介导的中枢神经系统损伤.
维生素D (Vit-D) 缺乏症在多发性硬化症患者中很常见,可能会影响疾病的发病性.
维生素D在MS中调节免疫系统的作用需要进一步阐明.

研究的目的:

研究维生素D补充剂对新诊断的多发性硬化症 (MS) 患者的细胞因子概况的影响.
评估维生素D水平,细胞因子平衡和早期MS的疾病活性之间的关系.

主要方法:

16名新诊断的,从未服用过药物的多发性硬化症患者被跟踪了12个月.
在基线和随访时测量了血清25-氧-Vit-D水平.
刺激了周围血液单核细胞 (PBMC) 来评估促炎 (TNF-α,IFN-γ,IL-6,IL-12) 和抗炎 (IL-4,IL-5,IL-10) 细胞因子的产生.

主要成果:

患者的维生素D水平在基线较低 (16.8 nmol/L).
维生素D补充剂,与或没有IFN-β1α免疫疗法,导致促炎细胞因子和促炎与抗炎细胞因子比率显著下降.
较高的基线亲炎和抗炎细胞因子比率与MS复发风险增加相关.

结论:

在早期MS中,低维生素D水平和高的促炎细胞因子表明低维生素D在疾病发展中的作用.
维生素D补充剂可以通过调节免疫-炎症反应,在MS中提供治疗益处.
这些发现凸显了维生素D在MS治疗中的潜在重要性.

关键词:

细胞因子 (cytokines) 是一种细胞因子.免疫反应的免疫反应.多发性硬化症是多发性硬化症.支持和抗炎性细胞因子.维生素D 维生素D是一种维生素.维生素D补充剂的使用

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