Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Avoidance Learning and Learned Helplessness01:14

Avoidance Learning and Learned Helplessness

1.7K
Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
1.7K
Fixed Action Patterns01:06

Fixed Action Patterns

15.8K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
15.8K
Preparedness and Phobias01:09

Preparedness and Phobias

91
Human fear responses to certain stimuli, such as darkness, heights, deep water, and blood, can often arise despite the absence of direct negative experiences. This phenomenon is rooted in evolutionary psychology, which posits that humans have developed a predisposition to fear stimuli that historically posed significant survival threats. This predisposition, known as preparedness, suggests that early humans who developed a fear of potentially dangerous entities, such as venomous snakes and...
91

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Exploring local and regional drivers of microbial biodiversity across freshwater ponds.

FEMS microbiology ecology·2026
Same author

Factors associated with treatment-emergent headache occurrence following RTMS to non-motor areas and the impact on treatment outcomes: a retrospective study.

Frontiers in psychiatry·2026
Same author

Time does the teaching.

Journal of experimental psychology. Animal learning and cognition·2026
Same author

A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation.

Cell·2026
Same author

The prefrontal cortex controls memory organization in the hippocampus.

Nature neuroscience·2026
Same author

The relationship between individual alpha-band activity and cognitive outcomes from repetitive Transcranial Magnetic Stimulation (rTMS) treatment for Major Depressive Disorder (MDD).

Journal of affective disorders·2026
Same journal

Proprioceptive cortical neurons implement optimal state estimation.

Current biology : CB·2026
Same journal

Coumarins link iron deficiency to TOR inhibition in plants.

Current biology : CB·2026
Same journal

Space-based monitoring of penguin diet links sea ice, food webs, and population change.

Current biology : CB·2026
Same journal

A global response contributes to tissue size robustness upon local induction of apoptosis.

Current biology : CB·2026
Same journal

Prebilaterian origin of monoaminergic signaling.

Current biology : CB·2026
Same journal

CLASP-dependent microtubule stabilization generates microtubule-based protrusive forces during Drosophila epithelial morphogenesis.

Current biology : CB·2026
查看所有相关文章

相关实验视频

Updated: May 28, 2025

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
11:18

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Published on: September 12, 2014

15.1K

快速威胁回避学习背后的前额头集体活动的转变.

Christopher J Gabriel1, Tanya A Gupta2, Asai Sánchez-Fuentes2

  • 1Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Current biology : CB
|February 12, 2025
PubMed
概括
此摘要是机器生成的。

动物很快学会通过使用安全位置来避免威胁. 在中间前额叶皮质 (mPFC) 中的前额叶皮质 (PL) 通过动态表示与威胁相关的行为来驱动这种避免学习.

关键词:
学习学习学习学习学习学习迷你望远镜成像成像技术这里是鼠标鼠标鼠标鼠标鼠标鼠标.前额叶皮层前额叶皮层.避免威胁 避免威胁

更多相关视频

Investigating the Neural Mechanisms of Aware and Unaware Fear Memory with fMRI
12:51

Investigating the Neural Mechanisms of Aware and Unaware Fear Memory with fMRI

Published on: October 6, 2011

12.8K
Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

7.5K

相关实验视频

Last Updated: May 28, 2025

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
11:18

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Published on: September 12, 2014

15.1K
Investigating the Neural Mechanisms of Aware and Unaware Fear Memory with fMRI
12:51

Investigating the Neural Mechanisms of Aware and Unaware Fear Memory with fMRI

Published on: October 6, 2011

12.8K
Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

7.5K

科学领域:

  • 神经科学是一个神经科学.
  • 行为科学 行为科学
  • 计算神经科学是一种神经科学.

背景情况:

  • 动物必须学会预测和避免生存的威胁.
  • 中间前额叶皮质 (mPFC) 的前额叶皮质 (PL) 对于整合学到的关联和指导威胁避免策略至关重要.
  • 功能失调的避开是情绪和焦虑障碍的标志,但避开学习背后的前额叶机制仍然不太了解.

研究的目的:

  • 研究在前临床皮质 (PL) 中避免学习的神经机制.
  • 了解PL神经活动如何在快速获得避免威胁行为的过程中发生变化.
  • 在避免学习过程中识别PL表示的时间动态.

主要方法:

  • 训练小鼠通过进入安全位置来避免被提示的威胁.
  • 迷你镜 (Ca2+) 成像被用来记录PL中神经活动在避免学习期间.
  • 分析重点是人口动态,试验结果预测和个体学习率.

主要成果:

  • 在学习早期,PL人口动态预测了试验结果,并跟踪了个体学习率.
  • 随着行为稳定,编码避免或探索的PL神经元被威胁信号调节.
  • 在即将到来的威胁中,PL迅速产生了新的回避或探索行动的表征.

结论:

  • 在快速生成避免学习表示中,PL起着至关重要的作用.
  • 在PL中神经活动在避免学习期间经历动态转变,反映了不断发展的行为策略.
  • 了解这些PL转换,可以了解适应性威胁回避的神经基础及其在焦虑障碍中的功能障碍.