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Updated: May 28, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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通过对MAPK/ERK通路的调节,增强T细胞转化为CART细胞的转化

Elham Adabi1, Filippos T Charitidis1, Frederic B Thalheimer2

  • 1Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Paul-Ehrlich-Strasse 51-59, 63225 Langen, Hessen, Germany.

Cell reports. Medicine
|February 12, 2025
PubMed
概括

生成仿真抗原受体 (CAR) T 细胞涉及病毒载体 (LVs). 这项研究揭示了CAR T细胞和非转化细胞之间的分子差异,突出了MAPK/ERK通路.

关键词:
卡尔-T细胞,晶状病毒载体,腺相关载体,干扰素刺激基因,MAPK/ERK通路,ERK2抑制剂.

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