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Updated: May 28, 2025

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突激素活性位点S4亚口袋的修改会对达比加特兰产生耐药性

Viola J F Strijbis1,2, Ka Lei Cheung1, Dejvid Veizaj1

  • 1Division of Thrombosis and Hemostasis, Department of Internal Medicine, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Thrombosis and haemostasis
|February 12, 2025
PubMed
概括

研究人员通过修改S4子站点来设计出对直接血栓激素抑制剂有耐药性的血栓激素变体. 这些经过修改的 (pro) 热血素变体对达比加特兰的敏感性降低,为新的抗凝固药物策略提供了潜力.

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