相关实验视频

Updated: May 5, 2026

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Published on: December 11, 2013

通过例行收集的数据进行终点评估,产生与随机对照试验数据可比的估计:对预防摔倒伤害的集群随机试验的分析

David A Ganz¹, Erich J Greene², Nancy K Latham³

¹Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Health Care Division, RAND, Santa Monica, CA, USA.

Journal of clinical epidemiology

|February 12, 2025

概括

在试验中,常规收集的数据 (RCD) 显示了类似的治疗效果估计,但可信度间隔更宽. 验证RCD结果需要测量临床试验终点的准确性不确定性.

科学领域:

临床试验方法论临床试验方法论
医疗保健服务研究医疗服务研究
在医疗保健中的数据科学.

背景情况:

常规收集的数据 (RCD) 越来越多地用于随机试验.
评估RCD有效性和精度的方法是有限的.
开发了一种方法来测量RCD有效性,相对精度和不确定性.

研究的目的:

开发和应用一种方法来测量RCD衍生结果的有效性和相对精度.
量化临床试验中与RCD相关的不确定性.
在STRIDE试验中,将RCD结果与常规确定的结果进行比较.

主要方法:

重新分析了"减少伤害和培养老年人信心的策略" (STRIDE) 试验的数据.
92%的参与者与RCD联系在一起.
估计的危险比率 (HRs) 和使用原始数据和RCD的置信区间 (CI).
计算HRs的有效率比率和相对精度的信任限值比率 (CLRs) 的比率.
使用引导来估计不确定性.

主要成果:

在RCD中,干预的HR为0.91 (95%CI:0.78-1.07),而在原始数据中为0.92 (95%CI:0.80-1.06).
HRs的比率为1.00 (95% CI:0.89-1.11),表明类似的有效性.
临床相关反应的比为1.03 (95% CI:0.96-1.06),表明精度略低.
对于HRs的置信区间是RCD的约3倍.
随着随访时间的延长,相对精度有所提高.

结论:

仅依赖RCD就产生了STRIDE中治疗效果的类似点估计和CI.
在RCD衍生结果的有效性估计方面存在重大不确定性.
未来的努力应优先考虑对临床试验终点RCD有效性的测量不确定性.

关键词:

集群随机试验的随机试验.跌倒伤害跌倒伤害医疗保险数据医疗保险数据精确度精确度精确度精确度常规收集的数据是常规收集的数据.有效性有效性是有效性的.

更多相关视频

Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults

Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults

Published on: December 9, 2014

Design and Analysis for Fall Detection System Simplification

Design and Analysis for Fall Detection System Simplification

Published on: April 6, 2020

相关概念视频

Nursing Assessment

Nursing Assessment

The two sources for collecting information are primary and secondary. After gathering information, interpretation and validation help to complete the data. The purpose of assessment is to establish data with the initial information, to interpret data about the patient's perceived needs and health problems, and to respond to these problems identified.
The nurse collects all aspects of the patient's health in the initial assessment, establishing priorities for ongoing focused assessments...

Data Collection III

Data Collection III

The physical assessment examines the patient for objective data that defines the patient's condition, and aids in formulating the nursing care plan. The purpose of physical assessment is a health status appraisal, which includes identifying health problems, and establishing a database for nursing intervention.
The principles to begin the physical assessment include conducting a comprehensive or problem-related history in a quiet, well-lit room, emphasizing privacy and comfort for the...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...