在阻塞性睡眠呼吸暂停综合征中肠道微生物组合的变化也与过度的白天嗜睡有关
Mariana Fernandes1, Orazio Palmieri2, Stefano Castellana3
1Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Brain research bulletin
|February 12, 2025
概括
阻塞性睡眠呼吸暂停综合征 (OSAS) 与成人肠道微生物组的变化有关. 在OSAS患者中,过度白天嗜睡 (EDS) 进一步区分了肠道细菌的组成,这表明潜在的肠-大脑轴连接.
科学领域:
- 微生物组研究的研究.
- 睡眠的药物 睡眠的药物
- 胃肠病学 胃肠病学
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 是各种并发病的已知危险因素.
- 在OSAS动物模型和儿科患者中观察到肠道微生物组的改变.
- 肠道微生物组在成人OSAS中的作用及其与过度白天嗜睡 (EDS) 的关联需要进一步研究.
研究的目的:
- 分析和比较成年OSAS患者与健康对照的肠道微生物组组成.
- 调查过度白天嗜睡 (EDS) 对OSAS患者肠道微生物群的影响.
主要方法:
- 在便样本上使用了16个元基因组学和生物信息学分析.
- 评估了肠道微生物组的组成,多样性和种群丰度.
- 为了进行比较分析,OSAS患者根据EDS严重程度 (爱普沃思睡眠度数 ≥10) 进行了分层.
主要成果:
- 与对照组相比,在OSAS患者中观察到肠道微生物群生物多样性的显著差异 (p<0.01).
- 在OSAS患者和健康个体之间确定了明显的细菌种群丰度概况.
- 在患有和没有EDS的OSAS患者之间,肠道微生物组的组成各不相同.
结论:
- 成人OSAS与肠道微生物组合的改变有关.
- 在OSAS患者中,过度白天嗜睡 (EDS) 似乎与明显的肠道微生物组特征相关.
- 在OSAS中对EDS的潜在肠介导作用需要进一步研究.
相关概念视频
Sleep Apnea
121
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
121
Other Pulmonary Disorders
798
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
798
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Sleep-Wake Cycles
1.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.2K
Insufficient Sleep and Sleep Deprivation
128
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
128
Respiratory Volumes and Capacities I
805
Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
805


