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基于丝素的水凝的银交叉连接,以提高稳定性和广泛的抗菌特性

Chavee Laomeephol^1,2, Apirujee Punjataewakupt³, Pawina Kanchanasin¹

¹Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand.

ACS applied bio materials

|February 12, 2025

概括

银离子 (Ag+) 稳定丝素水凝,增强其结构并产生有效的抗菌材料. 这一创新提高了生物材料的性能,用于各种应用.

科学领域:

生物材料科学生物材料科学
材料化学材料化学
生物技术是生物技术.

背景情况:

丝素 (SS) 具有有益的药物特性,如抗氧化活性和细胞支持.
SS的快速降解限制了其在实际应用中的使用.
开发稳定的基于SS的水凝对于先进的生物医学用途至关重要.

研究的目的:

研究银离子 (Ag+) 作为丝素 (SS) 水凝的交联剂.
提高SS水凝的结构完整性和功能性质.
评估Ag+交联SS水凝的抗菌性和细胞相容性概况.

主要方法:

用不同度的银离子 (Ag+) 来合成和交叉链接丝素 (SS) 水凝.
结构完整性通过水解和酶抗性测试进行评估.
使用基于细胞的测定来评估细胞相容性.
对细菌,真菌和酵母的小组进行了抗菌活性测试.

主要成果:

加入Ag+稳定了SS水凝网络,通过dityrosine交叉链和协调键.
与1mM Ag+交联的水凝显示结构完整性得到改善,细胞相容性保持,抗氧化活性保持.
这些优化的水凝对测试的病原体表现出广泛的抗菌活性.
较高的Ag+度导致细胞毒性增加,但没有改善抗微生物药物的有效性.

结论:

银离子 (Ag+) 有效地交叉链接丝素 (SS),产生稳定和功能性的水凝.
与Ag+交联的SS水凝显示出有希望的广泛的抗微生物特性.
这些材料代表了适用于抗微生物应用的可扩展,多功能3D结构.

关键词:

抗微生物活性的抗微生物活性.可生物降解的脚手架.细胞相容性细胞相容性基于丝素的水凝.银离子是银离子的一种.

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