乳清蛋白对脂质概况的影响:系统性审查和元分析
Ibrahim Saeed Gataa1, Z Abdullah2, María Verónica González Cabrera3
1Warith Al-Anbiyaa University, Karbala, 56001, Iraq.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|February 12, 2025
概括
在成年人中,乳清蛋白 (WP) 补充剂显著降低甘油三 (TG) 和增加高密度脂蛋白胆固醇 (HDL-c). 需要进一步的研究来探索对不同人群的长期影响.
科学领域:
- 营养科学 营养科学
- 生物化学 生物化学
- 临床营养学 临床营养学
背景情况:
- 脂质特征异常是心血管疾病的重要危险因素.
- 包括蛋白质补充剂在内的饮食干预措施正在探索管理脂质配置文件.
- 乳清蛋白 (WP) 是一种流行的从牛奶中提取的饮食补充剂.
研究的目的:
- 进行一项元分析,研究乳清蛋白 (WP) 补充剂对成年人脂质特征的影响.
- 综合随机临床试验的证据,以确定WP对甘油三 (TG),HDL-c,LDL-c和总胆固醇 (TC) 的影响.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Scopus,Google Scholar,Cochrane Library) 进行了系统的文献搜索,截至2024年5月.
- 包括1638名参与者在内的20项随机临床试验 (RCT) 被纳入了元分析.
- 使用随机效应模型汇集数据,计算加权平均差异 (WMDs) 以95%的置信区间 (CI).
主要成果:
- 乳清蛋白补充剂显示,三甘 (TG) 水平显著降低 (WMD: -12.21 mg/dL; P = 0.003).
- 观察到高密度脂蛋白胆固醇 (HDL-c) 的显著增加与WP摄入量 (WMD: 2.59 mg/dL; P = 0.001).
- 没有发现对总胆固醇 (TC) 或低密度脂蛋白胆固醇 (LDL-c) 水平有显著影响.
结论:
- 乳清蛋白补充剂有效地改善了成年人的甘油三和HDL-c水平.
- 目前的证据表明,WP不会显著改变总胆固醇或LDL-c.
- 在不同人群中进行进一步的长期RCT是有必要的,以充分阐明WP对脂质资料的影响.
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