代谢性酸与儿科炎症和肺炎中的感染严重程度有关
Hannah Brummer1,2, Hongyue Wang3, George J Schwartz4
1Division of Nephrology, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. hbrummer@upa.chob.edu.
代谢性酸症在儿科炎症中很常见,发生在84%的病例中. 较低的二碳酸盐水平与这些患者更长的住院时间和更多的发烧日相关.
科学领域:
- 儿科脏病学 儿科脏病学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 脊髓炎是儿童常见的严重细菌感染.
- 代谢性酸症是已知的发炎的并发症.
- 这项研究调查了儿科大肠杆菌炎中代谢酸性的发生率和影响.
研究的目的:
- 确定患有急性大肠杆菌炎的儿科患者代谢酸性症的频率.
- 为了比较肌炎与肺炎中的代谢性酸症的发病率和特征.
- 评估代谢性酸性疾病的临床意义,与感染严重程度和结果相关.
主要方法:
- 追溯性,单一中心的研究,小儿病患者住院治疗炎症或肺炎.
- 收集了nadir血清二碳酸盐和离子间隙值,以及可用的基线和恢复数据.
- 记录了血清电解质,肌素和感染严重程度的标志物.
主要成果:
- 84%的炎炎患者患有酸性结核,而肺炎患者的这一比例为66%.
- 与肺炎患者相比,肌炎患者的血清二碳酸盐 (20 mEq/L) 的平均最低值显著降低,离子间隙 (16 mEq/L) 较高.
- 酸性结核与炎症发烧持续时间的增加以及两组患者在医院住院时间的延长相关.
结论:
- 代谢性酸症在儿科炎症中非常普遍.
- 较低的二碳酸盐水平与长时间住院和发烧持续时间的增加有关.
- 这些发现突显了监测和管理儿科炎症中电解质平衡的临床重要性.
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