循环节障碍和发展肥胖症的风险
1Univ. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France. Helene.duez@pasteur-lille.fr.
Current obesity reports
|February 12, 2025
概括
循环节律的破坏有助于肥胖. 时间限制饮食 (TRE) 对肥胖管理具有前景,但需要进行更大规模的研究来确认其在不同人群和性别中的有效性.
科学领域:
- 时间生物学 时间生物学
- 代谢生理学 代谢生理学
- 肥胖问题研究研究
背景情况:
- 生物钟调节脂肪组织的功能.
- 循环节失调与肥胖和代谢障碍有关.
- 轮班工作和暴露于光线等环境因素会破坏昼夜节律.
研究的目的:
- 审查关于时钟在脂肪组织中的作用的证据.
- 为了检查昼夜失调对肥胖发展的影响.
- 评估时间限制饮食 (TRE) 作为一种肥胖干预措施.
主要方法:
- 评论最近的科学文献.
- 对涉及时钟基因 (老鼠模型) 遗传突变的研究进行分析.
- 关于时间限制饮食的人类研究的评估.
主要成果:
- 循环时钟影响脂肪生成,脂生成,脂解和热生成.
- 轮班工作,吃晚饭和暴露于光线与肥胖和相关疾病有关.
- 时间限制的饮食证明了益处,特别是对于那些心脏代谢风险较高的人来说.
结论:
- 循环节障碍是肥胖的一个重要因素.
- 时间限制的饮食是控制肥胖的一个有希望的策略.
- 需要进一步的大规模,受控的研究来验证TRE的有效性,并优化其应用,特别是轮班工作者.
相关概念视频
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Obesity
366
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
366
Insufficient Sleep and Sleep Deprivation
128
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
128
Cause and Effect
10.9K
While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
10.9K
Management of Insomnia
229
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
229
Psychoneuroimmunology: Diabetes and Cancer
22
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
22


