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Updated: May 28, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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高多基因风险分类的不稳定性和通过整合性评分来减轻风险

Anika Misra1,2, Buu Truong1,2, Sarah M Urbut1,2,3

  • 1Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Nature communications
|February 12, 2025
PubMed
概括

多基因风险评分 (PRS) 显示不一致的高风险分类. 综合性PRSmix框架 (ChronoAdd) 通过结合多个PRS来提高分类稳定性,提供可靠的高风险个体识别.

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