在超重和Helicobacter pylori感染的轻度痴呆症患者中补充黑是一种试点研究
Yohanes Tandoro1,2, Hui-Fang Chiu3, Chei-Ling Tan1
1Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan.
NPJ science of food
|February 12, 2025
概括
黑补充剂通过减少H. pylori感染和超重,改善了轻度痴呆症患者的认知功能. 这种干预也对肠道微生物平衡和炎症标志物产生了积极的影响.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 阿尔茨海默氏症 (AD) 是导致痴呆的主要原因,其中包括肠-大脑轴 (GBA) 因素,如H. pylori感染和超重.
- 人们越来越认识到肠道微生物在认知健康和痴呆症发展中的作用.
研究的目的:
- 研究黑 (BRB) 补充剂对H. pylori感染,超重和轻度痴呆症患者的认知功能的影响.
- 评估BRB对肠道微生物组合,炎症标志物和代谢指标的影响.
主要方法:
- 一项为期10周的随机化,安慰剂控制的临床试验,涉及轻度痴呆症患者,患有H. pylori感染和超重.
- 参与者每天两次接受25克黑粉或安慰剂.
- 主要结局包括临床痴呆评分 (CDR),尿素呼吸测试 (UBT) 和体重指数 (BMI) 的变化.
主要成果:
- 与安慰剂相比,BRB补充剂显著改善了认知功能 (CDR) (p < 0.00001).
- BRBs降低了H. pylori感染 (UBT) 和BMI (分别为p < 0.00001和p < 0.05).
- BRBs降低了炎症标志物,改善了氧化指数和皮菌素,以及调节的便益生菌,如Akkermansia muciniphila.
结论:
- 黑补充剂在抑制H. pylori感染,降低BMI和重新平衡肠道微生物群方面表现有前途.
- 这些效应可能有助于改善轻度痴呆症患者的认知功能.
- 需要进行更大规模的临床试验来证实这些试点发现.
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