综合分析LRRC42作为潜在的生物标志物和癌症发展中的关键细胞过程
Rongfu Huang1, Jianfeng Yao2, Lei Liu1
1Laboratory medicine, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, 362000, Fujian, China.
Scientific reports
|February 12, 2025
概括
含有白的富重复42 (LRRC42) 在许多癌症中升高,并与生存率低下有关. 向LRRC42可能会抑制瘤的进展,特别是在肝肝细胞癌 (HCC) 中.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 含有42的富含白的重复基因 (LRRC42) 是一种涉及细胞过程的基因.
- 它在各种人类癌症中的作用及其对瘤微环境的影响仍然不完全理解.
研究的目的:
- 研究LRRC42在多种癌症类型的瘤发育和进展中的作用.
- 探索LRRC42与预后,瘤免疫微环境和关键信号通路的关联,重点关注肝细胞癌 (HCC).
主要方法:
- 对癌症基因组图谱 (TCGA) 和TISCH2基因表达和单细胞数据数据库的分析.
- 相关性分析将LRRC42表达与临床结果,免疫细胞,上皮细胞-介质细胞过渡 (EMT),自和热症联系起来.
- 在HCC细胞系中使用LRRC42敲除的功能验证.
主要成果:
- 在许多癌症 (例如,BLCA,BRCA,LIHC) 中,LRRC42的表达是上调的,但在其他癌症 (例如,KICH,THCA) 中是下调的.
- 高LRRC42表达与几种瘤类型的预后不佳相关,并与特定的免疫细胞群和EMT,自和热的标志物有关.
- 在HCC中,LRRC42与Th2细胞共同表达,并与mRNA处理和细胞循环途径有关;它的敲击抑制了HCC细胞的增殖,迁移和入侵.
结论:
- LRRC42在促进癌症的发展和进展方面发挥着重要作用,特别是在HCC.
- LRRC42是癌症治疗的潜在治疗标,特别是通过调节关键细胞过程来抑制HCC的进展.
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