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皮质桃体在塑造社会接触中的关键作用
Antonio V Aubry1,2,3, Romain Durand-de Cuttoli1,2,3, Elizabeth Karpman1,2,3
1Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nature
|February 12, 2025
概括
研究人员在雄性小鼠中发现了特定的脑细胞, 抑制这些细胞降低了攻击性和增加了社会调查, 突出了攻击性的关键神经回路.
科学领域:
- 神经科学
- 行为生物学
- 遗传学
背景情况:
- 对于社会层次和资源保护而言, 侵略是一种保存的行为.
- 小鼠的攻击性行为包括食欲 (接近) 和食欲 (攻击) 阶段.
研究的目的:
- 确定参与男性攻击的脑部区域和神经回路.
- 研究后侧皮质桃体 (COApl) 中特定细胞在攻击性行为中的作用.
主要方法:
- 对小鼠全脑FOS表达的无监督加权相关性网络分析.
- 对COApl雌激素受体1 (Esr1) 表达细胞 (COAplEsr1) 的化学和光遗传学操纵.
- 对COAplEsr1投射到中腹下丘脑和中枢桃体的分析.
主要成果:
- 一组大脑区域,包括下丘脑,桃体和嗅觉皮质区域, 在男性攻击者中表现出协同激活.
- 在男性的攻击行为和之前的调查中,COAplEsr1细胞的活性很高.
- 抑制COAplEsr1细胞降低了攻击性,增加了亲社会调查,但没有影响社会奖励.
结论:
- 在雄性小鼠中,COAplEsr1细胞作为一个中心,对社会刺激做出反应,以促进攻击性.
- 从COAplEsr1到中腹下丘脑和中枢桃体的投射对于攻击性至关重要.
- 这些发现揭示了男性侵略的特定神经机制.
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