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不同营养干预措施对肝硬化患者肉症的有效性:系统性审查和网络元分析
Elham Sobhrakhshankhah1, Mohammad Farahmand2, Minoo Hasan Rashedi3
1Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
BMC nutrition
|February 12, 2025
概括
营养干预可以帮助管理肝硬化患者的. 宫术后的静脉支可以改善肌肉质量,而高热量饮食可以提高力量. 分支链氨基酸 (BCAA) 补充剂也可以提高肌肉的结果.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 营养科学 营养科学
- 老年病的医生 老年病的医生
背景情况:
- 肉,肌肉质量和力量的损失,在肝硬化患者中很普遍.
- 有效的营养干预措施对于管理这种人群的肉症至关重要.
- 不同营养策略的比较有效性尚不清楚.
研究的目的:
- 评估各种营养干预措施对肉病在肝硬化中的有效性.
- 通过对随机对照试验的元分析来综合现有证据.
- 为了比较不同营养方案对肌肉质量和力量的影响.
主要方法:
- 贝叶斯网络对14项随机对照试验 (RCT) 的元分析,涉及1437名患者.
- 在Scopus,PubMed,科学网和科克兰图书馆搜索到2024年12月.
- 通过GRADE通过P-score和证据质量评估干预排名.
主要成果:
- 后静脉输入营养支持与口服协议改善了肌肉质量 (MAMC).
- 高卡路里,高蛋白饮食 (HCHP) 和HINT饮食增强了肌肉力量 (手握).
- 分支链氨基酸 (BCAA) 补充剂,含有或不含维生素D,改善肌肉质量 (SMI) 和力量.
结论:
- 营养干预措施在肝硬化症中显示出对肉类的承诺,但证据确定性较低.
- 特定的方案是有效的肌肉质量 (静脉支) 和力量 (HCHP,HINT饮食).
- 补充BCAA对肌肉质量和力量都有好处.
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