在慢性乙型肝炎患者中,空气污染会导致异常的阿兰氨基转移酶水平
Tyng-Yuan Jang1,2,3, Yu-Ting Zeng4, Po-Cheng Liang2
1Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung, Taiwan, ROC.
Journal of the Chinese Medical Association : JCMA
|February 13, 2025
概括
暴露于细颗粒物 (PM2.5) 与使用核酸模拟疗法治疗的慢性乙型肝炎患者中较高的氨酸氨基转移酶水平有关. 这种关联在没有肝硬化的患者中更为显著.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 环境健康 环境健康
- 病毒学 病毒学
背景情况:
- 慢性乙型肝炎病毒 (HBV) 感染是一个全球性的健康问题.
- 核酸/核酸类似物 (NA) 是慢性HBV的标准治疗方法.
- 氨酸氨基转移酶 (ALT) 水平升高表明肝炎,并可能受到各种因素的影响.
研究的目的:
- 检查在接受NA治疗的慢性乙肝患者中空气污染暴露和ALT水平异常之间的关系.
- 为了确定与该患者队列中ALT升高相关的危险因素.
主要方法:
- 一项涉及1275名慢性乙型肝炎患者的横截面研究,这些患者接受了NAs治疗.
- 在2019年至2022年期间在高雄收集的数据.
- 从入学前一年的每日空气污染物度 (包括PM2.5) 的分析.
主要成果:
- 在NA治疗前,88.4%的患者表现出异常的ALT水平.
- 乙型肝炎病毒的DNA水平是异常ALT的主要风险因素 (OR:1.40).
- 颗粒物直径≤2.5μm (PM2.5) 度也与异常ALT (OR:1.05) 有显著关联,特别是在没有肝硬化的患者中.
结论:
- 增加的PM2.5度与NA治疗的慢性乙型肝炎患者的 elevated baseline ALT水平相关.
- 在没有肝硬化的患者中,PM2.5对异常ALT水平的影响更为明显.
- 应将空气质量视为慢性乙型肝炎管理中肝酶异常的潜在贡献因素.
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