降低维生素D水平对膝盖或关节骨关节炎的疼痛,功能和严重性的影响
Cláudia Nascimento Montemor1, Marcos Tadeu Parron Fernandes2, Audrey Souza Marquez3
1School of Medicine, Pontifical Catholic University of Parana (PUCPR), Londrina 86072-360, PR, Brazil.
Nutrients
|February 13, 2025
概括
低维生素D水平与骨关节炎 (OA) 的更糟糕结果有关,包括增加疼痛和功能下降. 这种缺乏也与较高水平的炎症标志物如TNF-α和IL-6相关.
科学领域:
- 老年学是指老年学的学科.
- 类风湿病学 类风湿病学
- 营养科学 营养科学
背景情况:
- 维生素D对于肌肉骨健康至关重要.
- 低维生素D与膝关节骨关节炎 (OA) 疼痛增加有关,但其对功能的影响还未得到充分研究.
研究的目的:
- 研究OA的老年人中维生素D缺乏和功能状态之间的关联.
- 探索维生素D缺乏与瘤亡因子α (TNF-α) 和介质素-6 (IL-6) 的血水平之间的相关性.
主要方法:
- 包括105名OA患者 (≥60岁) 和152名对照.
- 评估OA的严重程度和功能障碍,使用X光确认和WOMAC问卷.
- 从血液样本中测量了25 (OH) 维生素D,TNF-α和IL-6水平.
主要成果:
- 维生素D不足/缺乏与更严重的OA有关 (p=0.04).
- 在OA患者中,较低的维生素D水平与更大的功能障碍和疼痛相关 (rS=-0.25,p=0.01).
- 患有维生素D缺乏症的OA患者的TNF-α和IL-6水平显著更高 (p<0.05).
结论:
- 减少维生素D与更严重的部和膝盖骨关节炎,增加疼痛和功能障碍有关.
- 血清TNF-α和IL-6水平升高与OA中维生素D缺乏有关.
- 需要进一步的研究来了解维生素D在OA中的作用以及补充剂的益处.
相关概念视频
01:22Connective Tissue Cell Types
3.1K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.1K
01:25Role of Vitamins in Maintaining Bone Health
3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K