对患有MASLD的成年人进行基于生物活性物质的干预措施的评估:系统范围审查的结果
Deepa Handu1, Kim Stote2, Tami Piemonte1
1Academy of Nutrition and Dietetics, Chicago, IL 60606, USA.
Nutrients
|February 13, 2025
概括
本综述检查了与代谢功能障碍相关的脂肪性肝病 (MASLD) 的生物活性物质. 黄素和西利马林显示出有希望的结果,但对其他干预措施需要更多的研究.
科学领域:
- 肝病学和胃肠道学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是一种普遍的慢性肝病.
- 有效的干预措施对于管理MASLD及其相关的健康风险至关重要.
- 生物活性物质是MASLD管理的潜在治疗途径.
研究的目的:
- 系统地审查和总结有关成人MASLD生物活性物质干预措施的证据.
- 确定研究最多的生物活性物质及其报告结果.
- 评估有关这些干预措施有效性的研究现状.
主要方法:
- 在六个主要数据库中进行了全面的文献搜索.
- 包括的研究包括随机对照试验,前性队列研究和2000年至2023年间发表的系统性审查.
- 研究集中在接受生物活性物质干预的MASLD成年人群中.
主要成果:
- 131项初级研究和49项系统性审查被纳入了这一范围审查.
- 黄素 (黄) 和西利玛林 (乳) 是最常被研究的生物活性物质.
- 结果的异质性被注意到,共同关注的是肝脏健康,体重和代谢标志物.
结论:
- 目前正在探索各种生物活性物质用于MASLD治疗.
- 虽然库尔库和西利马林有实质性的证据,但需要进一步的研究来证实所有研究物质的临床疗效.
- 综合发现对于制定最终的治疗指南至关重要.
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