016 通过调节氧化应激,肠道微生物群和微生物代谢来缓解小鼠结肠炎
Huachun Pan1, Shumin Yang2, Md F Kulyar1
1College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Nutrients
|February 13, 2025
概括
乳酸菌发酵素016 (LF) 补充剂有助于通过改善肠道微生物群,增强甲酸代谢和减少炎症来管理性结肠炎 (UC). 这种益生菌对开发炎症性肠病 (IBD) 的精密疗法充满希望.
科学领域:
- 胃肠道学和微生物学
- 免疫学和新陈代谢
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病 (IBD),与肠道失调和代谢失衡有关.
- 益生菌如Lactobacillus fermentum 016 (LF) 缓解UC的确切机制尚未完全理解.
研究的目的:
- 在小鼠模型中评估LF补充对肠道健康的影响.
- 调查酸 (DSS) 诱导的UC中LF的预防作用和潜在机制.
主要方法:
- 在基底和DSS诱导的UC模型中给LF给C57BL/6小鼠.
- 分析肠道微生物群的组成,代谢活动 (特别是酸盐代谢),免疫标记物和肠道屏障功能.
- 评估疾病活动指数 (DAI),结肠长度和组织学损伤.
主要成果:
- 补充LF调节了肠道微生物群,增强了托代谢,并表现出免疫调节作用.
- 肺炎缓解了UC症状,包括体重减轻,腹,直肠出血和结肠缩短,同时减少炎症和改善抗氧化剂标志物.
- 乳清激活了Nrf2-Keap1通路,调节了全身炎症细胞因子,并恢复了有益的肠道细菌和托代谢物.
结论:
- 乳酸菌发酵素016在调节肠道微生物群的恒常性和增强托代谢方面显示出显著的潜力.
- 乳清有效地减轻UC症状和病理损伤,表明其作为IBD的益生菌治疗策略的实用性.
- 该研究提供了对LF在IBD管理中精确治疗开发机制的关键见解.
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