相关实验视频
Updated: May 5, 2026

10:19
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
14.2K
口服益生菌用于预防怀孕期间的复发性阴感染 - 多中心双盲,随机,安慰剂控制试验
Zohar Nachum1,2, Abeer Suleiman3, Raul Colodner4
1Department of Obstetrics & Gynecology, Emek Medical Center, Afula 1834111, Israel.
Nutrients
|February 13, 2025
概括
口服益生菌不能预防重复的阴道感染 (VVIs) 在孕妇. 这项研究发现,服用益生菌和服用安慰剂的女性之间的VVI率没有显著差异,这表明其对二次预防的有效性有限.
科学领域:
- 产科和妇科 产科和妇科
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阴道感染 (VVIs),包括异常的阴道菌群 (AVF),细菌性阴道炎 (BV) 和阴道候群 (VVC),在怀孕期间很常见.
- 这些感染与严重的并发症和母亲的不适有关.
- 在孕妇中,对VVI的二次预防策略至关重要.
研究的目的:
- 评估口服益生菌在孕妇VVI的二次预防中的有效性.
- 为了确定口服益生菌是否可以减少初始治疗后VVI的复发率.
主要方法:
- 一个多中心,前性,随机,双盲,安慰剂受控试验.
- 接受治疗的VVI的孕妇每天要么服用口服益生菌 (含有特定的Lactobacillus和Bifidobacterium菌株),要么服用安慰剂,直到分娩.
- 每个月或症状出现时监测阴道微生物群和VVI复发;使用MALDI-TOF-MS评估了特定益生菌菌株的殖民性.
主要成果:
- 在益生菌组 (67%) 和安慰剂组 (48%) (p = 0.19) 之间没有观察到总体VVI复发率的显著差异.
- 在两组之间,第一次感染和怀孕结果的时间没有差异.
- 在任何参与者身上都没有检测到被管理的益生菌菌株的阴道殖民.
结论:
- 经过测试的口服益生菌配方没有证明在减少孕妇VVI复发的有效性.
- 可能需要进一步的研究来探索替代益生菌菌株或用于怀孕期间预防VVI的输送方法.
- 目前的口服益生菌补充剂在本研究人群中对VVI的二次预防没有益处.
相关概念视频
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
1.7K
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
1.7K
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
2.5K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
2.5K
Probiotics
299
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
299
Development of Human Microbiota
68
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
68
Development of the Oral Microbiota
73
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
73
Microbiota of the Urogenital Tract
59
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
59

