Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bone Disorders01:29

Bone Disorders

3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

685
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
685
Bone Remodeling01:40

Bone Remodeling

38.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.1K
Regulated Protein Degradation02:58

Regulated Protein Degradation

7.1K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
7.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Adaptive islet biology and comprehensive incretin physiology: Emerging perspectives from Asia and Europe.

Journal of diabetes investigation·2026
Same author

Cardiovascular Efficacy of GLP-1 Receptor Agonists by Kidney Function: An Updated Meta-Analysis of Randomized Trials Including the SOUL Trial.

Diabetes, obesity & metabolism·2026
Same author

Response to Comment on Sakaki et al. Quantitative β-Cell Mass Imaging Redefines Disease Staging and Glycemic Control in Type 1 Diabetes.

Diabetes·2026
Same author

Longitudinal evaluation of recurrent thyrotoxicosis in a single patient across four pregnancies: a case report and literature review.

Endocrinology, diabetes & metabolism case reports·2026
Same author

Household Composition May Modify the Association Between Home Cooking and Dietary Diversity Among Japanese Corporate Employees.

Nutrients·2026
Same author

Sex-Dependent and Asymmetric Associations of Bodyweight History in the Twenties with Later HbA1c Trajectories in a Japanese Occupational Cohort.

Nutrients·2026

相关实验视频

Updated: May 28, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

4.3K

删除和轻微的蛋白质限制额外减少肌肉和骨质量和功能.

Kanako Deguchi1, Chihiro Ushiroda1, Shihomi Hidaka2

  • 1Department of Clinical Nutrition, Fujita Health University, Toyoake 470-1192, Japan.

Nutrients
|February 13, 2025
PubMed
概括
此摘要是机器生成的。

轻微的蛋白质限制和碳水化合物反应元素结合蛋白 (ChREBP) 缺失会对肌肉和骨健康产生负面影响. 保持足够的碳水化合物和蛋白质摄入量对于保持肌肉和骨质量和功能至关重要.

关键词:
骨矿物质密度 骨矿物质密度碳水化合物是一种碳水化合物.碳水化合物结合蛋白质是一种碳水化合物结合蛋白.胖胖胖的 胖胖的 胖胖的肌肉质量 肌肉质量 肌肉质量蛋白质蛋白质是蛋白质蛋白质的组成部分.

更多相关视频

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
07:34

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide

Published on: May 12, 2023

962
Inducible and Reversible Dominant-negative DN Protein Inhibition
08:35

Inducible and Reversible Dominant-negative DN Protein Inhibition

Published on: January 7, 2019

8.3K

相关实验视频

Last Updated: May 28, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

4.3K
Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
07:34

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide

Published on: May 12, 2023

962
Inducible and Reversible Dominant-negative DN Protein Inhibition
08:35

Inducible and Reversible Dominant-negative DN Protein Inhibition

Published on: January 7, 2019

8.3K

科学领域:

  • 代谢调节 代谢调节 代谢调节
  • 营养科学 营养科学
  • 肌肉骨健康 肌肉骨健康

背景情况:

  • 碳水化合物和蛋白质的限制与缩症和骨质疏松症有关,但机制尚不清楚.
  • 研究轻度蛋白质限制对野生型 (WT) 和ChREBP淘汰赛 (KO) 小鼠肌肉和骨的影响.

研究的目的:

  • 为了确定轻度蛋白质限制对WT和ChREBPKO小鼠肌肉和骨功能的影响.
  • 阐明导致潜在肌肉和骨缺陷的潜在机制.

主要方法:

  • 18周大的雄性WT和ChREBPKO小鼠被食控制 (20%蛋白质) 或低蛋白质 (15%蛋白质) 饮食12周.
  • 评估肌肉重量,四肢握力,骨矿物质密度 (BMD),骨结构和骨形态.

主要成果:

  • 删除ChREBP和低蛋白饮食增加地减少了体重,脂肪重量,肌肉重量和四肢握力.
  • 这些肌肉缺陷与胰岛素/IGF-1 mRNA的减少和肌静素 mRNA的增加有关.
  • 删除ChREBP增加了骨质量和骨结构完整性,但KO小鼠的蛋白质限制扭转了这些好处,减少了骨质量和硬度. 轻微的蛋白质限制只能在WT小鼠中减少骨形成标记物.

结论:

  • 无论是ChREBP删除还是蛋白质限制都会损害肌肉和骨功能,这表明ChREBP在肌肉骨健康方面发挥了作用.
  • 足够的碳水化合物和蛋白质摄入量对于维持肌肉和骨质量和功能至关重要.
  • 需要进一步的研究,以充分了解ChREBP删除和低蛋白饮食诱导的骨质沙症背后的机制.