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删除和轻微的蛋白质限制额外减少肌肉和骨质量和功能
Kanako Deguchi1, Chihiro Ushiroda1, Shihomi Hidaka2
1Department of Clinical Nutrition, Fujita Health University, Toyoake 470-1192, Japan.
Nutrients
|February 13, 2025
概括
轻微的蛋白质限制和碳水化合物反应元素结合蛋白 (ChREBP) 缺失会对肌肉和骨健康产生负面影响. 保持足够的碳水化合物和蛋白质摄入量对于保持肌肉和骨质量和功能至关重要.
科学领域:
- 代谢调节 代谢调节 代谢调节
- 营养科学 营养科学
- 肌肉骨健康 肌肉骨健康
背景情况:
- 碳水化合物和蛋白质的限制与缩症和骨质疏松症有关,但机制尚不清楚.
- 研究轻度蛋白质限制对野生型 (WT) 和ChREBP淘汰赛 (KO) 小鼠肌肉和骨的影响.
研究的目的:
- 为了确定轻度蛋白质限制对WT和ChREBPKO小鼠肌肉和骨功能的影响.
- 阐明导致潜在肌肉和骨缺陷的潜在机制.
主要方法:
- 18周大的雄性WT和ChREBPKO小鼠被食控制 (20%蛋白质) 或低蛋白质 (15%蛋白质) 饮食12周.
- 评估肌肉重量,四肢握力,骨矿物质密度 (BMD),骨结构和骨形态.
主要成果:
- 删除ChREBP和低蛋白饮食增加地减少了体重,脂肪重量,肌肉重量和四肢握力.
- 这些肌肉缺陷与胰岛素/IGF-1 mRNA的减少和肌静素 mRNA的增加有关.
- 删除ChREBP增加了骨质量和骨结构完整性,但KO小鼠的蛋白质限制扭转了这些好处,减少了骨质量和硬度. 轻微的蛋白质限制只能在WT小鼠中减少骨形成标记物.
结论:
- 无论是ChREBP删除还是蛋白质限制都会损害肌肉和骨功能,这表明ChREBP在肌肉骨健康方面发挥了作用.
- 足够的碳水化合物和蛋白质摄入量对于维持肌肉和骨质量和功能至关重要.
- 需要进一步的研究,以充分了解ChREBP删除和低蛋白饮食诱导的骨质沙症背后的机制.
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