果消费与超重/肥胖和慢性低度炎症患者的胰岛素敏感性增加有关
Katherine D Pett1, Peter Geevarghese Alex1, Casey Weisfuss1
1Center for Nutrition Research, Department of Food Science and Nutrition, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL 60616, USA.
Nutrients
|February 13, 2025
概括
定期摄入果可以改善成年人超重或肥胖和慢性轻度炎症的胰岛素敏感性. 这种饮食干预可以通过潜在地激活Nrf-2基因和增强抗氧化防御来增强葡萄糖代谢.
科学领域:
- 代谢健康 代谢健康
- 营养科学 营养科学
- 炎症研究 炎症研究
背景情况:
- 慢性低度炎症与胰岛素抵抗和血糖控制不良有关,增加了2型糖尿病 (T2DM) 的风险.
- 超重和肥胖是发展T2DM和相关炎症状况的重要危险因素.
研究的目的:
- 研究常规果消费对炎症和胰岛素敏感性的影响.
- 在超重/肥胖成年人接受4周的果干预后,评估代谢和炎症标志物的变化.
主要方法:
- 一个随机,受控,并行设计的临床研究.
- 参与者在果或对照产品摄入前4周和4周后接受了2小时的口服葡萄糖耐受性测试 (OGTT).
- 分析了禁食和OGTT后的血液样本,以检测代谢和炎症标志物.
主要成果:
- 与对照组相比,果摄入量显著降低了禁食胰岛素水平,改善了胰岛素耐药性 (HOMA-IR) 和排放指数 (DI).
- 在4周后,果组的平均胰岛素度在OGTT后显著下降.
- 炎症标志物 (IL-6,TNFα,hs-CRP) 和禁食葡萄糖没有显著变化.
- 在果组中观察到Nrf-2基因表达的非显著的两倍增加.
结论:
- 果的消费似乎可以提高慢性低度炎症患者的胰岛素敏感性.
- 潜在的机制包括Nrf-2基因激活和改善细胞抗氧化剂状态.
- 需要进一步的研究来探索果在控制胰岛素抵抗的饮食模式中的作用.
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