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老年营养风险指数 (GNRI) 和胰腺癌生存率:一项回顾性研究

Christina Grinstead¹, Saunjoo L Yoon¹

¹Department of Biobehavioral Nursing Science, College of Nursing, University of Florida, 1225 Center Drive, P.O. Box 100187, Gainesville, FL 32610-0187, USA.

|February 13, 2025

概括

诊断时较低的老年营养风险指数 (GNRI) 评分和随着时间的推移降低的GNRI评分预测胰腺癌患者的生存率降低. 早期识别GNRI营养风险可以指导干预措施以改善结果.

科学领域:

在瘤学瘤学.
营养科学营养科学
老年病的医生老年病的医生

背景情况:

营养不良显著影响胰腺癌患者的治疗结果.
瘤学中的营养评估缺乏标准化.
老年营养风险指数 (GNRI) 为营养风险评估提供了一个实用的工具.

研究的目的:

分析诊断时GNRI和随时间变化的GNRI与胰腺癌患者的整体存活率之间的关联.
评估GNRI作为胰腺癌生存的预测工具.

主要方法:

对314名胰腺癌患者 (年龄≥18岁) 的回顾性研究.
在诊断时和≥30天后计算的GNRI.
使用卡普兰-梅尔曲线和考克斯比例危险模型分析的生存率.

主要成果:

在诊断时任何营养风险 (GNRI ≤98) 的患者的中位生存时间 (442 vs. 1105天) 显着较低.
随着时间的推移,GNRI的严重下降与生存时间大幅减少 (372.5天) 相比,没有变化/增加 (1791天).
降低的GNRI得分 (轻度和重度) 独立预测了减少的生存率,即使在控制癌症阶段后.

结论:

较低和下降的GNRI得分是胰腺癌生存率下降的重要预测因素.
GNRI是一个潜在的有效和有效的工具,用于早期识别需要营养干预的高风险患者.
建议对更大的队列和多种变量进行进一步研究,以确认发现并探索混因素.

关键词:

老年人的营养风险指数卡赫西亚 (Cachexia) 是一种缓解症.营养状态营养状况胰腺癌是一种癌症.幸存率幸存率生存率减肥减肥减肥减肥减肥减肥

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