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年代型和癌症:从人类研究中,慢性营养和瘤学之间的新兴关系
Justyna Godos1,2, Walter Currenti1, Raffaele Ferri3
1Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
调整饮食时间与身体的自然昼夜节律,特别是通过早餐和长时间的夜间禁食,可以降低癌症风险. 这种时间营养方法支持新陈代谢健康和免疫功能.
科学领域:
- 营养科学 营养科学
- 时间生物学 时间生物学
- 在瘤学瘤学.
背景情况:
- 循环节律控制着日常生理过程,包括新陈代谢和免疫功能.
- 昼夜调整的干扰,特别是睡眠和饮食时间之间的干扰,可以创造一种亲致癌的代谢环境.
- 慢性营养学,即对时间限制的饮食的研究,探讨了饮食模式如何影响健康和疾病风险.
研究的目的:
- 审查关于慢性营养和癌症风险的人类研究.
- 探索潜在的机制,将饮食时间与癌症发展联系起来.
- 总结有关癌症的时间限制饮食和间歇性禁食的证据.
主要方法:
- 人类研究的系统审查.
- 分子和系统机制的分析.
- 检查时间型,时间限制的饮食和禁食协议.
主要成果:
- 一个早晨的时间型 (调整的饮食和昼夜节律) 与降低癌症风险有关.
- 早期的时间限制饮食和长时间的夜间禁食与较低的癌症发病率相关.
- 年代型通过细胞循环调节,代谢途径,炎症和肠道微生物群影响癌症风险.
结论:
- 新出现的证据表明,慢性营养策略,包括时间限制的饮食和间歇性禁食,可能会降低癌症风险.
- 虽然缺乏明确的指导方针,但将饮食模式与昼夜节律协调一致,对预防癌症有很大希望.
- 需要进一步的研究,以确定与时间相关的饮食模式的最终建议.
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