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Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
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The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
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Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

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隔离的白色狼蛋白有益地调节大鼠肠道微生物群的组成.

Luis A Rubio1, Giulia Chiesa2

  • 1Department of Animal Nutrition and Sustainable Production, Estación Experimental del Zaidin (CSIC), Profesor Albareda 1, 18008 Granada, Spain.

Nutrients
|February 13, 2025
PubMed
概括

白狼蛋白分离物 (LPI) 有利地调节大鼠肠道微生物群. 牛奶蛋白 (乳蛋白和乳酪蛋白) 也改变了微生物群,乳蛋白显示出比乳酪蛋白更健康的特征.

关键词:
狼 (Lupinus albus) 是一种白色狼 (Lupinus albus).卡西因 (casein) 是一种蛋白质.肠道微生物群的组成乳蛋白 (lactalbumin) 是一种乳蛋白.蛋白质分离物 蛋白质分离物鼠标 鼠标 鼠标 鼠标 鼠标

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科学领域:

  • 微生物学 微生物学
  • 营养科学 营养科学
  • 胃肠病学 胃肠病学

背景情况:

  • 众所周知,以豆类为基础的饮食可以积极影响肠道微生物群.
  • 这些有益作用部分归因于豆类的蛋白质成分.

研究的目的:

  • 研究不同蛋白质来源对大鼠便微生物群组成的影响.
  • 为了比较牛奶蛋白 (乳蛋白和乳酪蛋白) 与白色狼蛋白分离物 (LPI) 的作用.

主要方法:

  • 在28天的时间里,老鼠被食含有乳蛋白 (LA),素 (CAS) 或LPI的饮食.
  • 使用qPCR和Illumina测序分析了便微生物群的组成和功能.
  • 统计分析包括ANOSIM,区分分析,LEfSe和PCA.

主要成果:

  • 在三个饮食组中观察到微生物群组成和功能上的显著差异.
  • 与素和乳蛋白饮食相比,LPI饮食导致肠道细菌和Escherichia/Shigella的水平较低.
  • 与其他饮食相比,素饮食导致Bifidobacteria和Lactobacilli的减少.

结论:

  • 白狼蛋白分离物 (LPI) 可能有利地调节大鼠肠道微生物群.
  • 基于乳蛋白的饮食促进了与素相比更健康的微生物群组成.
  • 素饮食还调节了微生物群,可能改善了肠道排便频率和脂质代谢.