人参和L-卡尼丁在调节老鼠运动耐力和氧化应激中的作用

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Kakanang Posridee¹, Sajeera Kupittayanant², Pornthep Rachnavy³

¹Health and Wellness Research Unit, School of Food Technology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.

|February 13, 2025

概括

人参提取物和L-卡尼丁补充剂通过促进能量代谢和减少氧化压力,显著改善了大鼠的运动耐力. 这两种化合物都提高了参与线粒体生物发生的关键基因的调节.

科学领域:

运动生理学运动生理学
营养生物化学营养生物化学
分子生物学分子生物学

背景情况:

人参和L-卡尼丁是运动表现的热门食补充剂.
人参和L-卡尼丁对运动耐久性的协同作用尚未得到充分证实.
研究组合补充剂需要一个强大的动物模型.

研究的目的:

评估人参提取物和L-卡尼丁对大鼠运动耐力的影响.
探索潜在的机制,包括能量代谢和基因表达.
为了确定是否联合补充提供了增强的好处.

主要方法:

雄性Wistar大鼠被分配到对照组,人参,L-卡尼丁或联合治疗组.
补充剂每天给定一段时间,其中一半接受游泳运动.
通过尾部悬浮强迫游泳测试来测量运动耐力;进行生物化学和基因表达分析.

主要成果:

人参和L-卡尼丁在运动小鼠中显著提高了运动耐力.
补充剂增加了肝脏糖原含量,并上调了AMPKα1和PGC-1α基因表达.
氧化应激减少,其证据是MDA水平降低和SOD活性增加.

结论:

人参提取物和L-卡尼丁补充剂显示了增强运动耐力的潜力.
机制包括改善能量代谢,减少氧化应激,以及激活线粒体生物发生路径.
联合补充值得进一步研究,以优化运动表现.

关键词:

这就是AMPKK.对于L-卡尼丁来说,它是一种它们是PGC-1α.运动耐力运动耐力人参提取物提取物糖原糖原是一种糖原.肝脏肝脏肝脏肝脏肝脏肝脏线粒体生物发生是线粒体生物发生.肌肉肌肉肌肉肌肉肌肉氧化应激是一种氧化应激.

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