相关实验视频
Updated: May 12, 2026

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
Published on: March 2, 2020
精神分裂症中血脑屏障的破坏:洞察力,机制和未来的方向
Fangsong Zhang1, Jianye Zhang1, Xuexue Wang1
1Department of Medical Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
血脑屏障 (BBB) 功能障碍越来越多地与精神分裂症有关,涉及神经炎症和内皮问题. 本综述使用多种研究方法探讨了精神分裂症的BBB变化,为潜在的治疗提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 血管生物学 血管生物学
背景情况:
- 血脑屏障 (BBB) 对于中枢神经系统的平衡至关重要.
- BBB功能障碍与精神分裂症病理生理学有关,涉及神经炎症和内皮问题.
- 先进的神经成像,如动脉旋转标签 (ASL),有助于BBB透性研究.
研究的目的:
- 审查和综合关于精神分裂症BBB变化的证据.
- 探索这种情况中BBB功能障碍背后的机制.
- 检查抗精神病药物对BBB的影响.
主要方法:
- 死后研究的综合分析.
- 对血清和脑脊液生物标志物的分析.
- 复习先进的神经成像研究,包括ASL.
主要成果:
- BBB功能障碍是精神分裂症的一个关键因素.
- 机制包括紧结蛋白失调和神经血管单元功能障碍.
- 抗精神病药物对BBB具有双向作用.
结论:
- 在精神分裂症中,BBB完整性受到显著破坏.
- 了解BBB变化为新型诊断和治疗提供了潜力.
- 本综述整合了多学科证据,以推进精神分裂症研究.
更多相关视频
08:04Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
Published on: November 19, 2020
06:19Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
Published on: October 20, 2023
相关概念视频
The Blood-brain Barrier
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Schizophrenia
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia
Gut-Brain Axis