相关实验视频

Updated: May 28, 2025

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

基于SDS的多核聚电解质纳米囊作为帕克利塔克塞尔的新型纳米载体,通过保护线粒体来降低心脏毒性

Marzena Szwed¹, Anastazja Poczta-Krawczyk¹, Katarzyna D Kania^2,3

¹Department of Medical Biophysics, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143 St, 90-236 Lodz, Poland.

International journal of molecular sciences

|February 13, 2025

概括

新开发的基于SDS的纳米囊可以减少帕克利塔塞尔.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
心脏病学心脏病学

背景情况:

帕克利塔塞尔 (PTX) 是一种有效的抗癌药物,但会引起心脏毒性.
开发更安全的PTX药物输送系统对于临床应用至关重要.

研究的目的:

评估基于SDS的聚电解质多核纳米囊 (NCs) 作为PTX的载体.
为了确定这些NC是否可以减轻PTX诱导的心脏毒性.

主要方法:

合成的基于SDS的NCs具有聚L-氨酸 (PLL) 或PLL/聚L-氨酸 (PGA) 涂层.
在HL-1心肌细胞中评估了细胞毒性.
使用氧化图,流细胞计,显微镜和RT-PCR来评估细胞平衡.

主要成果:

与单独使用PTX或SDS/PLL/PGA/PTX相比,SDS/PLL/PGA/PTX纳米囊显著降低了心脏毒性.
在SDS/PLL/PGA/PTX中,线粒体平衡,ATP水平和细胞内的最小破坏.
这些纳米载体在心脏细胞中表现出良好的耐受性.

结论:

由于心脏毒性降低,SDS/PLL/PGA/PTX纳米囊对抗癌症治疗具有前景.
这些纳米载体为提高稳定性提供了改善帕克利塔克塞尔递送的潜力.

关键词:

在 LbL 技术上.导致心血管损伤.纳米颗粒是一种纳米粒子.纳税人就是纳税人.

更多相关视频

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

相关概念视频

Drugs that Stabilize Microtubules

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

Electron Transport Chain: Complex I and II

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...