低氧相关的长非编码RNA在癌症化学疗法耐药性中的作用
Muhammad Affan Elahi1, Aamira Tariq2, Ambrin Malik2
1Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
International journal of molecular sciences
|February 13, 2025
概括
缺氧诱导的长非编码RNAs (lncRNAs) 促进癌症转移和耐化疗. 针对这些与缺氧相关的lncRNAs,为有效的癌症疗法提供了一个有希望的策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 瘤微环境的标志性特征缺氧显著影响癌症的进展和患者的结果.
- 长非编码RNAs (lncRNAs) 是基因表达的关键调节者,参与各种细胞过程,包括瘤转移.
- 表皮介质转换 (EMT) 是一种由低氧驱动的关键机制,有助于癌细胞入侵和转移.
研究的目的:
- 研究缺氧诱导的长非编码RNAs (lncRNAs) 在癌症发展和转移中的作用.
- 在低氧条件下探索 lncRNAs 在化疗耐药性的参与.
- 确定与缺氧相关的lncRNAs作为癌症治疗的潜在治疗点.
主要方法:
- 在低氧瘤微环境中分析lncRNA表达特征.
- 研究上调 lncRNAs 对癌细胞迁移和入侵的功能影响.
- 评估缺氧诱导的lncRNAs与化疗耐药性之间的相关性.
- 生物信息分析以确定由低氧调节的关键 lncRNAs.
主要成果:
- 许多 lncRNAs 在对缺氧的反应中显著上调.
- 缺氧诱导的lncRNAs增强了癌细胞的迁移,入侵和转移.
- 这些lncRNAs在赋予化学疗法耐药性的过程中起着至关重要的作用.
- 特定的缺氧相关的lncRNA被确定为这些过程的关键驱动因素.
结论:
- 缺氧诱导的lncRNAs是癌症转移和化学抵抗的关键媒介.
- 准这些lncRNAs为改善癌症治疗结果提供了一个新的治疗途径.
- 对缺氧相关的lncRNAs的进一步研究可能会导致开发有效的抗癌策略.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
02:53Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
02:56Treatment Resistant Cancers
3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K