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Updated: May 28, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
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基于perhydroquinoxaline κ受体激活剂的立体选择性合成和生物评估

Jonathan Hoffmann1, Dirk Schepmann1, Constantin Daniliuc2

  • 1Institut für Pharmazeutische und Medizinische Chemie, Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.

International journal of molecular sciences
|February 13, 2025
PubMed
概括

研究人员设计了一种新型的氧化基诺素,一种潜在的卡帕阿片类受体激动剂,通过形状限制和极性组的添加. 这种化合物对卡帕受体表现出中度亲和力和高选择性.

关键词:
停靠的对接方式乙烯基二胺氨基 乙烯基二胺氨基通过基诺氨酸.伪奇拉性是一种伪奇拉性.立体选择合成合成转换配置的转换配置.κ κ受体亲缘关系的受体.κ受体激动剂的受体激动剂.

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