在动脉样硬化中mtDNA突变的作用:线粒体功能障碍对巨细胞极化的影响
Evgeniya I Fedotova1,2, Alexey V Berezhnov1,2, Daniil Y Popov2
1Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino 142290, Russia.
International journal of molecular sciences
|February 13, 2025
概括
线粒体DNA (mtDNA) 突变可能引发巨细胞极化,影响动脉样硬化. 本综述探讨了巨细胞中的线粒体功能及其与炎症性疾病中mtDNA突变的联系.
科学领域:
- 心血管研究研究心血管研究
- 细胞生物学 细胞生物学
- 线粒体医学 线粒体医学
背景情况:
- 动脉样硬化是心血管疾病的主要原因,其特征是炎症.
- 线粒体DNA (mtDNA) 突变越来越多地与动脉样硬化有关,但机制尚不清楚.
- 巨细胞是动脉样硬化的关键参与者,具有明显的M1 (促炎) 和M2 (抗炎) 现型的可塑性.
研究的目的:
- 审查和比较不同巨细胞极化状态 (M1与M2) 中的线粒体功能.
- 探索由mtDNA突变驱动的线粒体干扰的潜在作用,作为巨分极的内部触发因素.
- 调查mtDNA突变,线粒体功能障碍和动脉样硬化发展之间的关联.
主要方法:
- 在M1和M2巨细胞中对线粒体功能特征的比较分析.
- 关于线粒体DNA突变在炎症和动脉样硬化中的作用的文献综述.
- 探索巨细胞代谢概况与线粒体参与之间的联系.
主要成果:
- 巨细胞两极分化 (M1/M2) 与不同的线粒体代谢特征有关.
- 线粒体功能障碍,可能是由mtDNA突变引起的,可能会影响巨细胞两极分化.
- mtDNA突变可以作为亲或反atherogenic巨细胞表型的内源性触发器.
结论:
- 线粒体及其DNA (mtDNA) 对于调节巨细胞两极分化至关重要.
- mtDNA突变代表了一个潜在的内部因素,在动脉样硬化中驱动巨细胞表型.
- 需要进一步的研究来阐明连接mtDNA突变,线粒体功能和动脉样硬化的精确机制.
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