富含抗氧化剂的功能性食物和运动:通过Nrf2和相关途径解锁代谢健康
Halina Tkaczenko1, Natalia Kurhaluk1
1Institute of Biology, Pomeranian University in Słupsk, Arciszewski St. 22b, 76-200 Słupsk, Poland.
International journal of molecular sciences
|February 13, 2025
概括
结合富含抗氧化剂的食物和运动,可以激活Nrf2通路,改善新陈代谢健康. 这种协同方法提高了胰岛素敏感性,脂质代谢,并减少了慢性疾病管理的炎症.
科学领域:
- 营养生物化学 营养生物化学
- 运动生理学 运动生理学
- 分子医学是分子医学.
背景情况:
- 氧化应激和炎症是代谢障碍的关键驱动因素.
- 核因子红色素2相关因子2 (Nrf2) 途径是细胞防御抗氧化应激的关键调节者.
- 众所周知,功能性食物和运动会调节新陈代谢健康,但它们通过Nrf2的协同效应尚未完全阐明.
研究的目的:
- 审查富含抗氧化剂的功能性食物和运动对代谢健康的协同效应.
- 阐明这些协同效应背后的分子机制,特别是Nrf2通路的作用.
- 确定用于评估这些综合干预措施影响的新生物标志物.
主要方法:
- 在PubMed,SCOPUS,Web of Science,PsycINFO和相关审查参考清单中索引的研究的综合文献综述,截至2024年12月20日.
- 专注于研究饮食中的生物活性化合物 (多,黄,维生素) 与运动对Nrf2激活的相互作用.
- 探索与其他信号通路 (AMPK,NF-κB,PI3K/Akt) 和新生物标志物 (NAD+/NADH,GSH比,线粒体健康标志物) 的相互作用.
主要成果:
- Nrf2通路对于调解联合抗氧化剂食物摄入和运动的代谢益处至关重要.
- 协同激活Nrf2可以改善胰岛素敏感性,脂肪代谢,并减少炎症.
- 与AMPK,NF-κB和PI3K/Akt通路的相互作用有助于改善代谢健康.
- 像NAD+/NADH比率和GSH比率这样的新生物标志物显示出监测干预疗效的潜力.
结论:
- 结合富含抗氧化剂的饮食和定期炼,通过激活Nrf2和相关途径,为管理慢性疾病提供了一个有希望的策略.
- 这种协同方法具有预防和治疗代谢障碍,心血管疾病,神经退行性疾病,癌症和感染的潜力.
- 需要进一步的研究才能充分了解不同种群和疾病状态中的长期影响和分子复杂性.
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