综合计算分析揭示了暴露工人的早期遗传和表观遗传AML易感生物标志物
Silvia Vivarelli1, Cigdem Sevim2, Federica Giambò1
1Department of Biomedical and Dental Sciences, Morphological and Functional Imaging, Section of Occupational Medicine, University of Messina, 98124 Messina, Italy.
International journal of molecular sciences
|February 13, 2025
概括
研究人员确定了包括NFKB1在内的9个关键基因,作为暴露和职业暴露工人急性髓性白血病 (AML) 风险的早期生物标志物. 这些发现有助于制定有针对性的健康监测和预防战略.
科学领域:
- 环境健康 环境健康
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 是一种已知的致癌物质,引起严重的健康风险,特别是在工业环境中.
- 对的慢性职业暴露与急性髓性白血病 (AML) 和其他癌症有关.
- 遗传和表观遗传变化对诱导癌症易感性的作用需要进一步研究.
研究的目的:
- 为了确定暴露和AML风险的早期生物标志物.
- 分析暴露工人的基因表达,DNA甲基化和miRNA数据.
- 探索涉及二醇白血病发生的分子途径和网络相互作用.
主要方法:
- 对基因表达和DNA甲基化数据集 (GEO数据集) 的分析.
- 与分子通路,miRNA-target和蛋白质-蛋白质网络分析的整合.
- 识别放松调节的基因,DNA甲基化变化和调节性miRNAs.
主要成果:
- 在暴露于的工人中发现了9个放松调节的基因,NFKB1显示出高的歧视潜力.
- 在CXCR6和MELTF中观察到剂量依赖的DNA甲基化变化.
- 特定的miRNAs (let-7d-5p,miR-126-3p,miR-361-5p) 被确定为关键调节者.
- 功能性丰富分析将已识别的基因与免疫反应,炎症,细胞增殖和亡途径联系起来.
- 网络分析强调NFKB1,CRK和CXCR6是相关白血病发生的核心.
结论:
- 对暴露和AML易受性的早期生物标记指纹的新见解.
- 开发基于生物分子的职业健康监测的潜力.
- 支持面临风险的员工的个性化预防策略.
关键词:
通过DNA甲基化.急性骨髓性白血病 (AML) 是一种急性骨髓性白血病.暴露于二烯的情况计算研究是研究计算的.基因表达的基因表达方式miRNA 监管网络 miRNA 监管网络职业生物标志物 职业生物标志物职业健康 职业健康 职业健康风险评估 风险评估 风险评估更多相关视频
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