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针对PD-1/PD-L1信号通路进行癌症治疗:专注于生物标志物

Areti Strati^1,2, Christos Adamopoulos^2,3, Ioannis Kotsantis⁴

¹Analysis of Circulating Tumor Cells, Lab of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.

International journal of molecular sciences

|February 13, 2025

概括

针对PD-1/PD-L1通路的免疫检查点抑制剂 (ICI) 治疗在癌症治疗中显示出前景. 了解瘤微环境是识别那些对这些疗法有反应的患者的关键.

科学领域:

免疫学和瘤学
癌症免疫疗法癌症免疫疗法

背景情况:

PD-1/PD-L1轴是T细胞反应中的一个关键的免疫抑制途径,对免疫平衡至关重要.
瘤微环境的复杂性显著影响了癌症免疫治疗策略的成功.

研究的目的:

审查PD-1/PD-L1信号通路在癌症中的功能.
讨论正在接受抗PD-1/PD-L1治疗的患者的免疫学,基因组学,表观遗传学和转录组学情景.
为PD-1/PD-L1抗体提供正在进行的临床试验概述.

主要方法:

文献审查侧重于PD-1/PD-L1通路.
对癌症患者的免疫学,基因组和转录组数据的分析.
对抗PD-1/PD-L1疗法的临床试验数据的摘要.

主要成果:

免疫检查点抑制剂 (ICI) 治疗,包括抗PD-1/PD-L1,已经改变了各种恶性瘤的癌症治疗.
描述瘤微环境有助于区分ICI治疗的响应者和不响应者.
目前正在进行的研究旨在改善患者选择,了解耐药性机制,并发现新的生物标志物.

结论:

了解PD-1/PD-L1通路和相关的瘤景观对于优化免疫治疗至关重要.
对生物标志物和临床试验的进一步研究对于最大限度地提高抗PD-1/PD-L1疗法的疗效至关重要.

关键词:

在PD1/PD-L1中.基因组景观的基因组景观免疫检查点抑制剂免疫检查点抑制剂免疫学景观免疫学景观一个转录的景观.

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