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在青春期经历的慢性不可预测的轻度压力的长期影响可能因生理性而有所不同
Olesya M Shirokova1, Daria M Kuzmina1, Olga G Zaborskaya1
1Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, Russia.
International journal of molecular sciences
|February 13, 2025
概括
青少年时期的慢性不可预测的轻度压力 (CUMS) 在雄性和雌性小鼠中引起了不同的成年行为. 虽然天体细胞和SigmaR1表达没有变化,但在男性中IL-1β降低,在CUMS后,SigmaR1水平在两性中都增加.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 压力研究 压力研究
- 性别差异 性别差异
背景情况:
- 慢性压力神经生物学中的性别差异是不太了解的.
- 青少年的压力暴露可能会产生长期的神经生物学后果.
研究的目的:
- 调查青少年时期对慢性不可预测轻度压力 (CUMS) 的性别特异的神经生物学反应.
- 检查CUMS对成年雄性和雌性小鼠行为,星细胞,IL-1β和SigmaR1表达的长期影响.
主要方法:
- 青少年小鼠中的慢性不可预测的轻度压力 (CUMS) 范式.
- 在成年后代的行为模式分析.
- 海马CA1天体细胞的免疫组织化学.
- 实时PCR用于SigmaR1表达.
- 在大脑皮层同质化IL-1β水平的ELISA.
主要成果:
- CUMS在成年男性和女性中诱导了不同的行为模式.
- 在海马体中没有观察到天体细胞数量或形态的显著变化.
- 在CUMS之后,IL-1β水平在男性下降,但女性没有下降.
- 在CUMS暴露后,两种性别的SigmaR1水平都显著升高.
结论:
- 生物性别和年龄显著影响对慢性压力的反应.
- 像IL-1β和SigmaR1这样的特定神经生物学标志物显示出取决于性别的变化.
- 进一步的研究对于阐明压力反应和心理健康风险背后的性别特异机制至关重要.
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