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血激活水通过影响炎症和重塑阶段,改善了糖尿病老鼠的伤口愈合

Jovana Rajić¹, Nevena Grdović¹, Anđelija Marković²

¹Department of Molecular Biology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11108 Belgrade, Serbia.

International journal of molecular sciences

|February 13, 2025

概括

血激活水 (PAW) 通过减少炎症和改善原沉积,有效地加速糖尿病伤口愈合. 这种创新疗法在治疗糖尿病足和促进患者康复方面表现有前途.

科学领域:

生物医学工程生物医学工程
伤口治愈研究研究伤口治愈研究
再生医学是一种再生医学.

背景情况:

糖尿病足显著损害生活质量,并带来经济挑战.
糖尿病患者的延迟愈合源于高血糖,血液循环不良,感染,氧化应激和炎症.

研究的目的:

评估血激活水 (PAW) 在促进糖尿病大鼠的伤口愈合方面的疗效.
阐明PAW影响糖尿病伤口修复的潜在机制.

主要方法:

在对照和糖尿病大鼠中创建了两个全厚伤口.
用PAW治疗伤口,并监测15天.
评估了炎症细胞透,酶活性 (MPO,NAG),基因表达和原沉积.

主要成果:

在糖尿病老鼠中,PAW显著改善了伤口愈合,主要是通过调节炎症阶段.
PAW降低了炎症细胞数量,MPO和NAG活性,以及促炎性基因表达.
PAW增加了大约10%的原沉积,并降低了Mmp-9/Timp-1比率.

结论:

治疗PAW有效地加速糖尿病伤口愈合.
PAW 降低了炎症反应,并影响了细胞外矩阵周转.
在治疗慢性糖尿病伤口方面,PAW具有显著的潜力.

关键词:

原蛋白是一种原蛋白.糖尿病糖尿病患者糖尿病患者细胞外矩阵重塑细胞外矩阵重塑这是一种炎症炎症炎症炎症.矩阵金属蛋白酶-9的结构.用等离子体激活的水.伤口愈合伤口愈合

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