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Updated: May 28, 2025

Engineering and Evolution of Synthetic Adeno-Associated Virus AAV Gene Therapy Vectors via DNA Family Shuffling
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通过病毒复原蛋白的分子进化改善了复合腺相关病毒载体的产生

Thomas Steininger1,2,3, Veronika Öttl1,4, Linda E Franken5

  • 1Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.

International journal of molecular sciences
|February 13, 2025
PubMed
概括

工程设计的AAV Rep蛋白质增强了基因治疗载体的产生. 针对Rep变种的定向进化显著提高了病毒基因组包装效率,提高了总体载体产量.

关键词:
在 AAV AAV AAV 中.指导进化是指导进化的.蛋白质工程工程 蛋白质工程rAAV的生产生产.复制蛋白质的复制蛋白质

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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