非洲特异性ACE2多态体对Omicron BA.4/5 RBD结合和在ACE2-RBD蛋白质复合体内的Allosteric通信的影响

Victor Barozi1, Özlem Tastan Bishop1,2

  • 1Research Unit in Bioinformatics (RUBi), Department of Biochemistry, Microbiology and Bioinformatics, Rhodes University, Makhanda 6139, South Africa.

概括

人类ACE2 (hACE2) 基因变异影响SARS-CoV-2尖端蛋白如何结合,可能影响病毒感染力. 这项研究检查了非洲人群中六种常见的 hACE2 多态,揭示了它们如何改变与Omicron BA.4/5尖端蛋白的相互作用.

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