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人类疾病中的lncRNA GAS5/miRNA/mRNA网络的表观遗传调节
Lam Ngoc Thao Nguyen1,2, Jaeden S Pyburn1,2, Nhat Lam Nguyen1,2
1Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
International journal of molecular sciences
|February 13, 2025
概括
长非编码RNA (lncRNA) 和微RNA (miRNA) 相互作用调节基因表达并影响疾病. GAS5在疾病进展中的双重作用为有针对性的干预提供了治疗潜力.
科学领域:
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 疾病机制 疾病机制
背景情况:
- 长非编码RNAs (lncRNAs) 和microRNAs (miRNAs) 是基因表达的关键表观遗传调节者.
- 增长停止特异性5 (GAS5) 是一种 lncRNA,它参与关键的细胞过程,如增殖,分化,衰老和亡.
- GAS5/miRNA网络影响了各种人类病理的疾病发展和进展.
研究的目的:
- 探索GAS5/miRNA网络在人类疾病中的二元作用.
- 阐明GAS5通过miRNA途径对疾病的细胞类型特定调制.
- 审查操纵GAS5用于疾病干预的治疗潜力.
主要方法:
- 关于GAS5,miRNA及其在疾病中的作用的现有科学文献的审查.
- 分析详细说明GAS5通过miRNA介导途径对蛋白质表达的影响的证据.
- 评估GAS5作为癌症瘤抑制剂的功能及其在非癌症疾病中的更广泛作用.
主要成果:
- GAS5表现出取决于情境的效应,既减轻疾病进展,又加剧疾病进展.
- GAS5通过与miRNAs的相互作用影响炎症和细胞死亡途径.
- 确立了GAS5在癌症中的瘤抑制作用,在非癌症条件下出现的证据.
结论:
- GAS5/miRNA网络在人类疾病中发挥着复杂的双重作用,包括癌症,心血管疾病,病毒感染和炎症性疾病.
- 了解GAS5的调节功能对于开发有针对性的治疗策略至关重要.
- 对GAS5调制的进一步研究有望为一系列疾病的新型干预措施提供希望.
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