炎症指数在急性肺栓塞的预后价值
Mihai Ștefan Cristian Haba1,2, Oana Mădălina Manole1,2, Ana Maria Buburuz1,2
1Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Diagnostics (Basel, Switzerland)
|February 13, 2025
概括
血液炎症标志物如中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 可以预测高风险急性肺栓塞 (PE) 和住院死亡率. 这些指数为管理PE患者提供了宝贵的预后见解.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 血液学 血液学 血液学
背景情况:
- 急性肺栓塞 (PE) 是致病率和死亡率的重要原因.
- 识别高风险PE患者对于及时干预至关重要.
- 炎症和血栓形成在PE病理生理学中起着关键作用.
研究的目的:
- 评估各种血液细胞指数在急性PE的预后价值.
- 评估中性粒细胞与淋巴细胞的比率 (NLR),淋巴细胞与单细胞的比率 (LMR),血小板与淋巴细胞的比率 (PLR),中性粒细胞与淋巴细胞的血小板比率 (NLPR),全身免疫炎症指数 (SII),全身炎症反应指数 (SIRI) 和全身炎症总指数 (AISI) 与PE风险和死亡率的相关性.
主要方法:
- 分析了157名确诊急性PE患者的队列.
- 根据简化肺栓塞严重程度指数 (sPESI),患者被分为高风险和低风险组.
- 进行了物流回归和接收器操作特征 (ROC) 曲线分析,以评估指数的预测能力.
主要成果:
- 在单变量分析中,右心室功能障碍,NLR,SII和SIRI与高风险PE有关.
- 在多变量分析中,NLR,PLR和NLPR被确定为高风险急性PE的独立预测因素.
- NLR,NLPR,SII和SIRI与住院死亡率有显著的相关性,特定的AUC值表明预测能力.
结论:
- 血细胞指数,包括NLR,NLPR,SII和SIRI,与高风险的急性PE和住院死亡率有关.
- 右心室功能障碍,NLR和NLPR是识别高风险急性PE患者的独立预测因素.
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