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一个循环miRNAs的系统审查通过多个独立研究验证了喉癌的循环miRNAs

Andreea Banta¹, Felix Bratosin², Ioana Golu^3,4,5

¹Doctoral School, Department of General Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.

Diagnostics (Basel, Switzerland)

|February 13, 2025

概括

本综述确定了循环的microRNAs (miRNAs) 作为喉状细胞癌 (LSCC) 的有前途的生物标志物. 像miR-21-5p这样的特定miRNA在LSCC患者中显示出早期诊断和预后的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

喉平细胞癌 (LSCC) 是一种普遍存在的头癌,患病率和死亡率很高.
循环微RNAs (miRNAs) 正在成为癌症检测和预后的敏感,非侵入性生物标志物.

研究的目的:

系统地审查和识别与LSCC相关的循环miRNA.
强调通过多项独立研究验证的miRNAs,以提高可靠性和临床适用性.

主要方法:

在PubMed,Scopus和Web of Science数据库中进行了广泛的文献搜索,截至2024年10月.
包括与人类参与者的研究,定量miRNA表达数据和临床相关性分析.
进行数据提取和质量评估,重点关注在多项研究中报告的miRNA.

主要成果:

包括9项研究,包括660名LSCC患者和212名对照.
一致确定了miR-21-5p (上调,与晚期,转移,生存率差相关),miR-125b-5p和miR-126-3p (下调,与晚期,差异化相关) 和miR-27a-3p (上调,预后差).
miR-33a-5p显示出作为具有高灵敏度和特异性的诊断生物标记物的潜力.

结论:

特定的循环miRNAs (miR-21-5p,miR-125b-5p,miR-126-3p,miR-27a-3p,miR-33a-5p) 是LSCC的有希望的生物标志物.
一致的发现支持它们在早期检测,预后和治疗向方面的潜在临床实用性.
临床实施需要在更大,更多样化的群体中进一步验证和检测方法的标准化.

关键词:

喉癌是一种喉癌.瘤外科手术是一项瘤外科手术.瘤学在瘤学方面.系统性审查系统性审查

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