吸入氧化对机械通风COVID-19患者的中期影响
Lev Freidkin1,2, Tamar Garsiel Katz3, Ido Peles3,4,5
1Pulmonary Division, Rabin Medical Center, Petah Tikva 4941492, Israel.
吸入的氧化 (iNO) 在严重的COVID-19 ARDS患者中改善了氧化. 这种治疗显示效果持续长达96小时,这表明目前的指导方针可能需要重新考虑.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧化 (NO) 对于生理功能至关重要.
- 吸入NO (iNO) 已被用于急性呼吸困难综合征 (ARDS).
- 由于COVID-19的流行,人们对iNO的兴趣增加了COVID-19 ARDS.
研究的目的:
- 为了评估吸入氧化 (iNO) 在严重的COVID-19 ARDS患者的疗效.
- 评估iNO对氧化和通风参数的影响.
- 确定iNO是否需要在治疗指南中重新考虑.
主要方法:
- 对87名患有严重COVID-19ARDS和耐火性低氧化血症的成年患者进行了回顾性研究.
- 患者需要机械通风,并接受iNO治疗.
- 氧化的改善定义为PaO2/FiO2比率与基线相比增加≥20%.
主要成果:
- iNO独立地与显著的PaO2/FiO2比率改善有关 (OR 1.26).
- 男性的最大氧化改善发生在14.5±5.0小时,女性的最大氧化改善发生在78.5±5.5小时.
- 氧化的改善持续了长达96小时.
结论:
- 严重的COVID-19 ARDS患者可能受益于吸入的氧化.
- 氧化改善可以延迟,持续长达96小时.
- 女性反应较慢表明潜在的性别特异性影响,这需要对指导方针进行审查.
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