局部晚期直肠癌的治疗管理:现有和未来的方法
Horia-Dan Lișcu1,2, Nicolae Verga1,2, Dimitrie-Ionuț Atasiei1
1Department of Oncological Radiotherapy and Medical Imaging, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Journal of clinical medicine
|February 13, 2025
概括
总的新辅助疗法 (TNT) 改善了生存率,并减少了直肠癌的复发. 新的策略和器官保存正在推进治疗,提供个性化的护理和更好的生活质量.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 放射疗法是一种放射治疗.
背景情况:
- 结直肠癌 (RC) 的发病率正在上升,特别是在年轻人中.
- 局部晚期直肠癌 (LARC) 管理正在随着新的治疗策略而发展.
- 总的新辅助疗法 (TNT) 已经成为一个重大进展.
研究的目的:
- 审查目前对直肠癌的治疗策略.
- 综合了直肠癌管理的最新进展.
- 探索直肠癌护理的未来创新.
主要方法:
- 对评估TNT的临床试验 (例如RAPIDO,OPRA,PRODIGE 23) 的审查.
- 对新辅助化学疗法和化学辐射疗法组合的分析.
- 探索器官保存策略,如观察和等待 (WW).
主要成果:
- TNT提高了整体生存率,并降低了转移和局部复发率.
- TNT促进了瘤治疗的完成,并增强了瘤的衰退阶段.
- 关于新辅助性放射治疗的遗漏,以减少毒性,争论仍在继续.
结论:
- 对于LARC患者来说,TNT提供了更好的结果.
- 器官保存策略和个性化医疗是未来的关键方向.
- 放射基因组学和人工智能集成有望优化直肠癌治疗.
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