三糖/高密度脂蛋白比率与心力衰竭发病风险之间的关联:基于人口的队列研究
Yoon-Kyung Chang1, Ju-Young Park2,3, Tae-Jin Song4
1Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea.
Journal of clinical medicine
|February 13, 2025
概括
甘油三和高密度脂蛋白 (TG/HDL) 的比率是胰岛素抵抗的标志物,与心力衰竭 (HF) 风险的增加有关. 这种关联对于患有和没有糖尿病的人来说都是正确的.
科学领域:
- 心血管疾病流行病学
- 代谢综合征研究 代谢综合征研究
- 生物标记分析 生物标记分析
背景情况:
- 甘油三和高密度脂蛋白 (TG/HDL) 的比率是胰岛素耐药性的公认指标.
- 胰岛素抵抗是心血管疾病的已知危险因素,包括心力衰竭 (HF).
- 对于事件HF的TG/HDL比率的预测值需要进一步调查.
研究的目的:
- 研究TG/HDL比率与心力衰竭 (HF) 的发病风险之间的关联.
- 确定这种关联是否在有糖尿病史 (DM) 和没有糖尿病史的个体中存在差异.
主要方法:
- 利用来自韩国国家健康保险服务-健康查队列数据库 (2002-2019) 的数据.
- 采用多变量时间依赖的Cox比例危险模型,重复测量TG/HDL比率.
- 使用国际疾病分类第十次修订代码I50.0.使用定义的事件HF.
主要成果:
- 总共分析了293,968名参与者,平均随访时间为9.6年.
- 每个单位增加的TG/HDL比率显著与高风险增加有关 (HR: 1.007,95% CI: 1.002-1.011).
- 与最低四分位数相比,最高的TG/HDL比率四分位数显示HF风险明显更高 (HR: 1.114,95% CI: 1.075-1.155).
结论:
- TG/HDL比率独立地与患心力衰竭的风险增加有关.
- 这种关联在一般人群中观察到,无论糖尿病状况如何.
- TG/HDL比率是心力衰竭发病率的一个有价值的预测标记.
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