在炎症性肠病中预测疾病激活中对托芬及其代谢物的评估
Ali Karataş1, Tarkan Karakan1, Nergiz Ekmen1
1Department of Gastroenterology, Faculty of Medicine, Gazi University, Ankara 06560, Turkey.
Journal of clinical medicine
|February 13, 2025
概括
血清酸 (TRP) 和其代谢物,特别是TRP与C反应蛋白 (CRP) 的比率,在预测炎症性肠病 (IBD) 激活方面表现有前途. 这种新的方法与便calprotectin (FC) 一起提供了补充的见解.
科学领域:
- 胃肠病学 胃肠病学
- 生物标志物发现发现
- 炎症性肠道疾病研究研究
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),涉及具有可变疾病活性的慢性炎症.
- 目前对IBD的诊断和监测工具需要加强,以准确预测疾病激活.
研究的目的:
- 调查血清酸盐 (TRP) 和其代谢物作为预测IBD疾病激活的潜在生物标志物.
- 为了比较TRP代谢物的预测性能与已建立的生物标志物,如便calprotectin (FC).
主要方法:
- 一项前性研究涉及115名IBD患者 (77名UC,38名CD).
- 血清TRP和代谢物水平通过液体染色学-并联质谱法 (LC-MS/MS) 测量.
- 使用ELISA分析便calprotectin (FC) 水平;临床和内镜评估疾病活性.
主要成果:
- 血清TRP水平显示72.1%的灵敏度和62.7%的特异性预测疾病激活.
- 便calprotectin (FC) 显示了84.2%的敏感性和67.6%的特异性.
- TRP与C反应蛋白 (CRP) 的比率 (TRP/CRP) 实现了卓越的诊断准确性,AUC为0.847.
结论:
- TRP/CRP比率成为预测IBD疾病激活的新型,全面的生物标志物.
- 虽然FC仍然是黄金标准,但TRP及其代谢物为IBD管理提供了有价值的补充信息.
- 建议在更大的患者队伍中进一步验证,以确认TRP/CRP比率的临床实用性.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
304
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
304
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
114
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
114
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
141
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
141
Inflammatory Bowel Disease IV: Pharmacological Management
99
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
99
Irritable Bowel Syndrome I: Introduction
231
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
231
Inflammatory Bowel Disease II: Crohn's Disease
171
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
171

![Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F63025.jpg&w=3840&q=50)
